NAD+ 5-in-1 Complete Mitochondrial Formula | NMN + CoQ10 + B-Complex + Antioxidants + Skin

Five longevity systems in one daily capsule — NAD+ precursors, mitochondrial cofactors, antioxidants, collagen-synthesis cofactors, and skin-hydration support. Built for people who want one bottle that covers most of the longevity-and-beauty bases without managing five separate purchases.

The 30-second answer

• One capsule, five active systems. NAD+ precursors (NMN + Niacin) + mitochondrial cofactors (CoQ10 + full B-complex) + antioxidant defense (Vitamins C + E) + collagen-synthesis cofactors (Vitamin C-dependent prolyl-4-hydroxylase + lysyl hydroxylase) + skin-hydration support (Hyaluronic Acid precursors).
• Best for: people who want a comprehensive baseline and don't want to assemble a multi-bottle stack themselves — or anyone whose previous attempt at a 5-bottle longevity stack ended with three of the bottles sitting unused.
• The trade-off, plain: the dose of each individual ingredient is lower than dedicated single-ingredient products. If you want maximum dose of one specific compound (e.g. 1000 mg NMN, 600 mg trans-Resveratrol, 400 mg CoQ10), use the standalone version. This product is engineered for breadth, not depth.
• Take 2 capsules with breakfast, daily. Several ingredients (Vitamin E, CoQ10) absorb materially better with meal fat — eat the capsules with the meal, not on an empty stomach.

What "5-in-1" actually means — and why we chose these five

Most "complete longevity" formulas are either (a) a single NAD+ precursor with a vitamin or two thrown in for marketing, or (b) a 30-ingredient kitchen-sink blend at homeopathic doses with everything hidden inside a "proprietary blend" so you can't see the actual amounts. Neither is honest engineering.

The five systems in this formula were chosen because they are the five places where biological aging actually starts to fail at the cellular level — and where missing one breaks the others:

• NAD+ pool (precursors): NAD+ is the coenzyme behind cellular energy, DNA repair, and sirtuin-pathway longevity signaling. It declines roughly 50% by age 50 (Massudi 2012, PLoS One; Camacho-Pereira 2016, Cell Metabolism). Without enough NAD+, the rest of the chain has no fuel.
• Mitochondrial cofactors (CoQ10 + B-complex): NAD+ is necessary but not sufficient. The electron transport chain still needs CoQ10 to shuttle electrons from Complex I/II to Complex III, and the Krebs cycle still needs B1 (thiamine), B2 (riboflavin → FAD), B3 (niacin → NAD+ pool), B5 (pantothenic acid → coenzyme A), B6 (pyridoxal-5-phosphate), and B12 to actually run. Raising NAD+ without the cofactors is like adding more fuel to a car with a clogged fuel injector.
• Antioxidant defense (Vitamins C + E): mitochondria leak ~1–2% of their electrons as superoxide during normal operation (Murphy 2009, Biochem J). Vitamin C (water-soluble, neutralizes radicals in the cytoplasm and plasma) and Vitamin E (fat-soluble, neutralizes lipid peroxidation in the membrane) are the two-front defense. They regenerate each other (Packer 1979, Nature).
• Collagen-synthesis cofactors: Vitamin C is the rate-limiting cofactor for the prolyl-4-hydroxylase and lysyl-hydroxylase enzymes that crosslink procollagen into the stable triple-helix that gives skin, joints, and connective tissue their structure. Scurvy is what total Vitamin C deficiency looks like — collagen synthesis fails. Even subclinical insufficiency degrades skin recovery.
• Skin hydration (HA precursors): Hyaluronic Acid binds up to 1,000× its weight in water; native production drops sharply after 40 (Stern 2007, Eur J Cell Biol). Oral HA precursors raise dermal HA over weeks (Kawada 2014, Nutr J; Oe 2017, Clin Cosmet Investig Dermatol).

Every active is dose-disclosed on the label. No proprietary blends. If a "complete formula" hides its individual ingredient amounts inside a single "proprietary blend" weight, that's almost always because at least one of the doses is too small to be effective at the price they're charging.

Per-system mechanism deep dive

System 1 — NAD+ precursors (NMN + Niacin)

Two precursors, one pool. NMN (nicotinamide mononucleotide) raises NAD+ via the most direct salvage pathway (NMN → NAD+ via NMNAT enzymes). Niacin (nicotinic acid) feeds the Preiss-Handler pathway. Using both gives more consistent intracellular NAD+ in different tissue compartments — the liver tends to favor the niacin route while peripheral tissue favors NMN/NR (Trammell 2016, Nat Commun; Yoshino 2018, Cell Metab).

The trade-off this formula makes: dose. The NMN dose here is moderate. If the strongest NMN response in the published literature is what you're after — Yoshino's 2021 Science trial dosed 250 mg/day, Igarashi's 2022 NPJ Aging dosed 250 mg, and Pencina's 2022 iScience dosed up to 900 mg — the dose-response peaks around 600–1000 mg/day. For that ceiling, see NMN 1000 mg Double Strength. For breadth across five systems with NAD+ included, this 5-in-1 is the design.

System 2 — Mitochondrial cofactors (CoQ10 + full B-complex)

CoQ10 (ubiquinone) is the electron carrier between Complex I/II and Complex III of the inner mitochondrial membrane. Endogenous synthesis declines from age 30 onward; statin medications block its synthesis directly via the same HMG-CoA-reductase inhibition that lowers cholesterol (Folkers 1990, PNAS; Marcoff 2007, J Am Coll Cardiol).

The full B-complex matters because the TCA cycle and oxidative phosphorylation are a relay race — if any cofactor is missing, the whole chain stalls at that step:

• B1 (Thiamine) — cofactor for pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (α-KGDH). Without B1, glucose can't enter the TCA cycle.
• B2 (Riboflavin) — precursor of FAD, the prosthetic group for Complex II of the electron transport chain.
• B3 (Niacin) — precursor of NAD+ itself, the coenzyme used at Complex I.
• B5 (Pantothenic acid) — precursor of coenzyme A, the carrier that delivers acetyl groups into the TCA cycle.
• B6 (Pyridoxal-5-phosphate) — required for amino acid → TCA-cycle entry and heme synthesis.
• B12 (Methylcobalamin) — required for the methionine cycle (which feeds methylation reactions across the body) and for myelin maintenance in nerve tissue.

For a high-dose dedicated CoQ10, see CoQ10 400 mg Maximum Strength — particularly if you're on a statin.

System 3 — Antioxidant defense (Vitamins C + E)

The mitochondria are the cell's biggest source of reactive oxygen species. Even healthy mitochondria leak about 1–2% of the electrons they handle as superoxide. The body uses a layered defense:

• Vitamin C — water-soluble, scavenges radicals in the cytoplasm and plasma, regenerates oxidized Vitamin E back to its active form (Packer 1979, Nature).
• Vitamin E (mixed tocopherols) — fat-soluble, sits inside the lipid bilayer of the cell membrane and the inner mitochondrial membrane, stops the chain reaction of lipid peroxidation that propagates membrane damage.

For a maximum-absorption Vitamin C focus, see Liposomal Vitamin C 1000 mg. The C in this 5-in-1 is the dose needed to support collagen synthesis and antioxidant recycling — the liposomal product is for people who want a dedicated 1000 mg high-bioavailability single ingredient on top.

System 4 — Collagen-synthesis cofactors

This is the system most "longevity" formulas miss entirely. Vitamin C is non-substitutable as the cofactor for prolyl-4-hydroxylase and lysyl-hydroxylase — the enzymes that hydroxylate proline and lysine residues in pre-procollagen, which is the step that lets three procollagen strands wind into a stable triple-helix (Myllyharju 2003, Matrix Biology). Skin, tendons, ligaments, blood vessels, bone matrix all depend on this. Subclinical Vitamin C insufficiency degrades collagen recovery long before frank scurvy appears.

If you're stacking a dedicated collagen peptide with this 5-in-1, you've covered both sides — the peptide supplies the amino-acid bricks, the Vitamin C in this formula supplies the crosslinking-enzyme cofactor. See Marine Collagen 5000 mg and Multi-Collagen Peptides Powder.

System 5 — Skin hydration (HA support)

Native dermal hyaluronic acid drops by roughly half between ages 40 and 70 (Stern 2007, Eur J Cell Biol). Oral HA precursors raise dermal HA over 8–12 weeks (Kawada 2014, Nutr J; Oe 2017, Clin Cosmet Investig Dermatol). For a dedicated 200 mg HA + 100 mg Vitamin C SKU at full trial-dose strength, see HA 200 mg + Vitamin C.

How the 5 systems integrate — the biochemistry maths

This is the section most "complete formula" pages skip, because the integration is what justifies a five-system bundle in the first place. The five systems aren't five independent benefits — they're five layers of one cellular energy and structural-protein chain. The maths tells you why missing any one of them blunts the effect of the other four.

1. The NAD+ ceiling — and why the precursor dose alone isn't the constraint

NAD+ functions as both a redox cofactor and a substrate consumed by sirtuins, PARPs, and CD38. Tissue NAD+ concentrations sit roughly in the 200–500 µM range in healthy young adults and drop measurably with age (Massudi 2012, PLoS One; Cantó & Auwerx 2012, Pharmacol Rev; Imai & Guarente 2014, Trends Cell Biol). SIRT1 has a reported Km for NAD+ of ~100–200 µM (Cantó 2012); SIRT3 (mitochondrial) and SIRT6 (chromatin) have similar mid-µM Km values (Kanfi 2012, Nature). Translation: when intracellular NAD+ falls into the lower end of that range, sirtuin activity falls non-linearly even before NAD+ becomes "deficient." Adding precursors raises the pool — but only if the salvage and de-novo enzymes (NMNAT1/2/3, NRK1/2, NAPRT) have the cofactors they need. Several of those cofactors are B-complex vitamins. So a precursor dose without B-complex support is a partial intervention; this 5-in-1 closes that loop.

2. ATP-per-glucose accounting — what the B-complex actually buys you

Complete oxidation of 1 glucose molecule yields roughly 30–32 ATP (the textbook number is 36–38; the corrected number accounts for the ATP cost of mitochondrial transport — Hinkle 2005, Biochim Biophys Acta). The breakdown:

• Glycolysis: 2 ATP net (substrate-level phosphorylation), plus 2 NADH that feed the electron transport chain.
• Pyruvate → Acetyl-CoA (the "gate" into the TCA cycle): 2 NADH per glucose. Requires B1 (thiamine pyrophosphate), B2 (FAD), B3 (NAD+), B5 (CoA), and lipoic acid. Without B1 specifically, this step fails — Wernicke's encephalopathy is the clinical end-state.
• TCA cycle: 2 ATP / GTP + 6 NADH + 2 FADH2 per glucose. Requires B1, B2, B3, B5, B6 — every step uses one of them.
• Electron transport chain + ATP synthase: ~26–28 ATP per glucose, generated when NADH (Complex I) and FADH2 (Complex II) feed electrons through the chain. Requires CoQ10 (between Complex I/II and III), B2 (FAD prosthetic group on Complex II), and B3 (NAD+ pool feeding Complex I).

What that means in plain English: if you raise NAD+ but the B-complex cofactors are insufficient, your cell has fuel but no fuel pump. The 5-in-1 design is to raise NAD+ and supply the cofactors that turn that NAD+ into actual ATP. Houtkooper 2010 (Endocrine Rev) reviewed the integration of NAD+, sirtuins, and mitochondrial cofactors as one circuit rather than three separate ones; this formula is built on that view.

3. The Vitamin C / Vitamin E redox couple — stoichiometric regeneration

Vitamin E (α-tocopherol) sits in the lipid bilayer and intercepts peroxyl radicals during lipid peroxidation. When it does, it becomes the α-tocopheroxyl radical — itself a mild oxidant. Vitamin C (ascorbate) regenerates α-tocopherol from the tocopheroxyl radical at a 2:1 stoichiometry (one ascorbate molecule, two electrons donated, gives one regenerated tocopherol; Packer 1979, Nature; Niki 1995, Free Radic Biol Med). The dehydroascorbate produced is then recycled back to ascorbate by glutathione (which itself depends on the precursor pool covered by other products in the catalog — see NAC 600 mg). This is why supplementing only Vitamin E without Vitamin C is leaky — the tocopheroxyl radical accumulates and can act as a pro-oxidant. Both together is the design.

4. Collagen synthesis — Vitamin C is rate-limiting, and the maths tell you the ceiling

One mature collagen fibril is built from procollagen molecules, each of which is a triple-helix of three polypeptide chains, each chain ~1,000 amino acids long, with hydroxyproline at roughly every third Y-position in the Gly-X-Y repeat. That's on the order of ~300–400 hydroxyproline residues per polypeptide chain × 3 chains ≈ 900–1,200 hydroxylation reactions per procollagen molecule — every one of which requires prolyl-4-hydroxylase, every one of which consumes one O₂, one α-ketoglutarate, and one Fe²⁺, and every one of which requires ascorbate to keep that Fe²⁺ from being oxidized to Fe³⁺ (which inactivates the enzyme; Myllyharju 2003, Matrix Biology). Lysyl-hydroxylation adds a similar requirement for the crosslinking step. Translation: collagen synthesis is a high-flux Vitamin C consumer. Skin and connective-tissue turnover continually depletes plasma ascorbate. The collagen-synthesis-cofactor function isn't an aside — it's why scurvy presents as a structural-protein collapse before it presents as anything else.

5. Hyaluronic acid — turnover speed sets the dose-response timeline

HA is a glycosaminoglycan polymer of repeating glucuronic-acid + N-acetylglucosamine disaccharide units, sometimes 10,000–25,000 units long, total molecular weight up to ~10 million Da (Stern 2007, Eur J Cell Biol). Total body HA in a 70 kg adult is roughly 15 g, and turns over with a half-life of ~1 day in skin, ~3–5 minutes in plasma, and as long as several weeks in cartilage (Fraser 1997, J Intern Med). The skin half-life is what makes oral HA dose-response visible — skin is the most rapidly remodeling HA depot, which is why the trial-readout windows for oral HA (Kawada 2014, Nutr J; Oe 2017, Clin Cosmet Investig Dermatol) come in at 8–12 weeks. Faster than that and you're seeing measurement noise; slower and the substrate ceiling has already saturated.

The integration in one sentence

Raise NAD+ (Systems 1) → it gets used as a coenzyme on the ETC and a substrate by sirtuins → which only works if CoQ10 + B-complex are present (System 2) → the resulting ATP and the resulting ROS are buffered by the C/E redox couple (System 3) → which also supplies the rate-limiting cofactor for collagen synthesis (System 4) → which integrates with the HA-substrate layer (System 5) to give the structural-protein and skin-hydration outputs the user actually sees in the mirror. Every link in that chain depends on the prior link being supplied. That's the formula's logic.

Cross-references to the Protocol collections

If you want to dig deeper on any one of the five systems, the catalog has dedicated collections that cover the wider product set for each layer:

• System 1 (NAD+ precursors): NAD+ Family collection · NMN Supplements collection. Single-ingredient ceiling-dose options, NR alternatives, liposomal/liquid format options, and the CD38-inhibitor add-ons (Apigenin, Quercetin) that protect the NAD+ pool from degradation.
• System 2 (Mitochondrial cofactors): Mitochondrial Renewal collection. Standalone CoQ10 at 400 mg, PQQ for biogenesis (PGC-1α — Chowanadisai 2010, J Biol Chem), Urolithin A for mitophagy (PINK1/Parkin — Andreux 2019, Nat Metab), and CaAKG as TCA-cycle substrate.
• System 3 (Antioxidant defense): Antioxidants collection. Glutathione precursors (NAC), Astaxanthin (membrane-spanning), Liposomal Vitamin C at 1000 mg, and the SOD/catalase-supporting cofactors.
• System 4 (Collagen-synthesis cofactors): Collagen Supplements collection for the substrate side (marine + multi-collagen), plus Skin Protocol collection for the integrated stack.
• System 5 (Skin hydration / HA support): Beauty & Anti-Aging collection. Standalone HA at 200 mg with Vitamin C, Biotin for keratin synthesis, and the integrated beauty stacks.
• Cross-system framework: Longevity Essentials for the catalog-wide foundational set, Our Science for the López-Otín 2023 Hallmarks-of-Aging framework that organizes the catalog by mechanism layer, and Protocols for stacks built around specific goals (Cellular Longevity, Beauty & Skin, Fertility, Cardiovascular, Brain & Cognitive, Metabolic).

One-bottle vs multi-bottle stack — which to pick

This is the most common honest question we get about the 5-in-1, so we'll answer it directly:

• Pick this if: you want simplicity, you're new to longevity supplementation, you want to cover beauty + longevity in one purchase, you're traveling and don't want a kit of bottles, or you've tried multi-bottle stacks before and stopped because the routine got unmanageable.
• Pick the multi-bottle stack if: you want maximum dose of any specific compound (e.g. 1000 mg NMN, 600 mg Resveratrol, 400 mg CoQ10), have specific goals (just metabolic health → Berberine; just skin → HA + collagen; just NAD+ ceiling → NMN 1000), or already know which pathways you want to push hardest.
• Or both: some customers take this 5-in-1 as the daily baseline and add one or two single-ingredient products to push specific pathways harder. That's a reasonable middle path — the 5-in-1 covers the breadth, the standalone covers the depth where it matters most for their goal.

The dedicated single-ingredient products in our catalog:

• Pure NMN 500 mg or NMN 1000 mg — for maximum NAD+ precursor dose.
• Resveratrol 600 mg — for sirtuin (SIRT1) activation. Not in this 5-in-1 formula.
• CoQ10 400 mg Maximum Strength — for high-dose mitochondrial support, especially on statins.
• Liposomal Vitamin C 1000 mg — high-dose, high-absorption antioxidant.
• HA 200 mg + Vitamin C — full trial-dose hydration support.
• Calcium Alpha-Ketoglutarate 1000 mg (CaAKG) — TCA-cycle substrate + epigenetic-clock cofactor (TET/JmjC demethylases). Not in this 5-in-1.
• Berberine HCL 500 mg — AMPK pathway, glucose metabolism. Not in this 5-in-1.

For a full picture of how to layer single-ingredient products on top of (or instead of) a one-bottle baseline, see our Longevity Stacking Protocol.

Where the 5-in-1 sits in the NAD+ family

The NAD+ family in our catalog covers different parts of the NAD+ landscape. None of them are redundant — they each solve a different problem:

• This 5-in-1 — NAD+ precursors plus the mitochondrial / antioxidant / collagen / skin systems they feed. Best for people who want one bottle covering breadth.
• Pure NMN 500 mg — single-ingredient, dose-focused. Best for trial-dose NMN at moderate strength.
• NMN 1000 mg Double Strength — same compound, ceiling dose. Best for the upper end of the published NMN dose-response curve.
• NAD+ Daily Boost Capsules (Direct NAD+ + Trans-Resveratrol) — direct NAD+ molecule plus SIRT1 activator co-formulated. Best for people who want NAD+ without going through the precursor pathway.
• Liposomal NAD+ Ultimate 1000 mg — encapsulated for higher bioavailability. Best for non-responders to standard NAD+ precursors.
• Liquid NAD+ Anti-Aging Drink — drink-format, stick packets. Best for capsule-fatigue or travel.

Who this is for

• Adults 30+ wanting a comprehensive longevity-and-beauty baseline without research-paralysis.
• People starting their first longevity protocol who want one product to take consistently before deciding what to add or replace.
• Anyone whose previous attempts at multi-bottle stacks ended with most bottles sitting unused — format compliance is real, and three months of consistent breadth beats two weeks of "perfect" depth.
• Travelers — single bottle covers most of the protocol when you're on the road.
• People on statins (combined with our dedicated CoQ10 400 mg if statin-induced CoQ10 depletion is a specific concern).
• People in their 30s and 40s who want to build a longevity habit without committing to a 6-bottle daily routine before they know which pieces matter most for their body.

Who this is NOT for

• People who already know they need a maximum-dose single-ingredient — e.g. 1000 mg NMN for cycling around a known dose-response, or 400 mg CoQ10 specifically for statin-induced depletion. Pick the standalone instead.
• Anyone with a known sensitivity to niacin flush — if you flush at 50 mg of niacin you'll feel the dose in this product. Niacinamide-only products avoid the flush; let us know if you want a redirect.
• Pregnant or breastfeeding women — limited safety data on combined longevity stacks during pregnancy. Consult your OB before starting.
• Anyone on chemotherapy or being treated for cancer — discuss with your oncologist; some longevity pathways (sirtuin, AMPK, NAD+) interact in non-trivial ways with cancer biology and treatment timing.
• People with known kidney or liver disease — review with your physician before any new supplement stack.

Week-by-week — what to expect

• Days 1–14: usually subtle. Multiple pathways activating simultaneously builds gradually rather than dramatically. Don't expect a "feel" the first week — feel-effects are not how this category works.
• Weeks 2–4: easier mornings, steadier afternoon energy, improved exercise recovery, nail strength often the first cosmetic signal (B-vitamins + collagen-synthesis cofactor compound).
• Weeks 4–8: mental clarity, exercise recovery, hydration improvements compound. Skin tends to look more even by the 6-week mark.
• Weeks 8–12: visible skin and hair improvements; sustained NAD+ and antioxidant support. The HA + Vitamin C + B-complex combination starts to show in skin texture around 8–12 weeks (matching the Proksch 2014 collagen-trial timeline + Kawada 2014 HA-trial timeline).
• Months 3+: long-term anti-aging mechanisms compound with continued daily use. The NAD+ effect on energy and the collagen/HA effect on skin both have a "compound" quality — the curve flattens but doesn't reverse if you keep taking it.
• If you stop: the NAD+ pool returns to baseline within 1–2 weeks (the salvage pathway is dynamic). Skin/hair benefits regress over 8–12 weeks (the structural protein turnover timescale).

Stacking with this product

The 5-in-1 is designed to be a complete daily baseline. If you want to push specific pathways harder while keeping the breadth, common add-ons are:

• + Resveratrol — for stronger sirtuin (SIRT1) activation. Resveratrol is the SIRT1 piece this 5-in-1 doesn't include. Resveratrol 600 mg.
• + Berberine — if metabolic health is a goal (the AMPK pathway, not in this formula). Pairs naturally with NAD+ precursors. Berberine HCL 500 mg Maximum Strength.
• + Marine Collagen — if you want stronger skin/hair structural support beyond the synthesis cofactors. The Vitamin C in this 5-in-1 is the cofactor; marine peptides are the substrate. Marine Collagen 5000 mg.
• + TMG (Trimethylglycine) — methyl donor that recycles homocysteine. Worth considering if you're at the higher dose end of NMN/NAD+ supplementation, since NAD+ metabolism uses methyl groups. TMG 1000 mg.
• + CaAKG — substrate for the TCA cycle and the epigenetic-clock demethylases (TET/JmjC). The 5-in-1 covers the NAD+ pool and the cofactors; CaAKG covers the substrate side and the epigenetic-remodeling layer. Calcium Alpha-Ketoglutarate 1000 mg.
• + Apigenin — CD38 inhibitor that slows NAD+ degradation, complementing the precursor strategy in the 5-in-1. Apigenin 50 mg.
• + Magnesium Glycinate — universal cofactor across >300 enzymatic reactions; deficiency is common and silently undermines the rest of the stack. Magnesium Glycinate 400 mg.

Directions

Take 2 capsules daily with breakfast. Several ingredients (Vitamin E, CoQ10) absorb materially better with meal fat — eggs, avocado, nut butter on toast, full-fat yogurt, olive oil on the salad all work. Daily consistency matters more than dose timing for this category — pick the time of day you're most likely to be reliable.

For more on supplement timing, see our timing guide.

What's in each capsule (per serving = 2 capsules)

• NAD+ precursor blend — NMN + Niacin (B3) at moderate breadth-formula doses (full per-ingredient amounts on the supplement-facts panel; no proprietary blends).
• CoQ10 (Ubiquinone) — for electron transport chain support.
• Full B-complex — B1 (Thiamine), B2 (Riboflavin), B5 (Pantothenic acid), B6 (Pyridoxal-5-phosphate / P5P), B12 (Methylcobalamin).
• Vitamin C — collagen-synthesis cofactor + antioxidant + Vitamin E recycling.
• Vitamin E — mixed tocopherols, lipid-membrane antioxidant.
• Hyaluronic Acid precursors — for skin-hydration support.

Vegetarian capsule (HPMC). No artificial colors, no proprietary blends, no fillers beyond the capsule shell. Third-party tested for purity.

Quality & sourcing

Manufactured in cGMP-certified facilities. Third-party tested for heavy metals (lead, arsenic, cadmium, mercury), microbial limits, and active ingredient potency. Certificate of Analysis available on request. Store in a cool, dry place; keep the bottle sealed when not in use.

Safety & cautions

• Niacin flush: if you're flush-sensitive, take with food and start with 1 capsule for the first 3–5 days, scale to 2.
• Vitamin K-related anticoagulation: this formula does not contain Vitamin K, but if you're on warfarin, review any new supplement with your physician.
• Pregnancy / breastfeeding: not recommended without OB clearance — limited data on combined longevity stacks during pregnancy.
• Active cancer treatment: discuss with your oncologist before starting — sirtuin/AMPK/NAD+ pathways have non-trivial interactions with cancer biology and chemotherapy timing.
• Kidney or liver disease: review the full ingredient panel with your physician.
• Surgery: stop 1–2 weeks before any planned surgery (precautionary; some longevity actives can affect bleeding or anesthesia metabolism).
• Drug interactions: if you're on metformin, statins, blood thinners, blood-pressure medication, antidepressants, or chemotherapy, review with your physician.

Frequently asked questions

Why isn't Resveratrol in the formula?

Resveratrol is fat-soluble and benefits from a different formulation strategy (often piperine for absorption, oil delivery for bioavailability), and the dose-response data is strongest at 250–600 mg/day — which is too large to fit alongside five other systems in two capsules. We kept Resveratrol as a dedicated standalone (Resveratrol 600 mg) and built the 5-in-1 around the NAD+/mitochondrial/antioxidant/collagen/HA stack instead. Many customers take both — the 5-in-1 as the daily baseline, Resveratrol added on top for SIRT1 activation.

Will I still benefit from this if I'm already taking standalone NMN?

Yes, and there are two ways customers handle it. Option A: replace the standalone NMN with this 5-in-1 to consolidate. Option B: keep the standalone NMN for the higher dose ceiling and add this 5-in-1 for the breadth (CoQ10 + B-complex + antioxidants + collagen cofactor + HA). The B-vitamins, CoQ10, and HA in this product don't overlap with NMN's NAD+ precursor function — they cover entirely different systems.

Why two capsules instead of one?

The five systems together require more material than will physically fit in one standard capsule shell. Splitting across two also gives slightly more even absorption across the meal window. Take both at once — you don't need to space them.

How does this compare to a multivitamin?

A standard multivitamin is built around recommended-daily-allowance (RDA) doses to prevent deficiency. This formula is built around longevity-and-beauty doses — NMN and CoQ10 are not in standard multivitamins, and the B-complex, Vitamin C, Vitamin E, and HA are at functional doses, not RDA-floor doses. A multivitamin and this 5-in-1 cover different problems; some customers take both.

Can I take this with coffee?

Yes. Coffee doesn't materially impair absorption of any of the actives in this formula. Take with breakfast (the meal fat helps with the fat-soluble actives) and have your coffee with or after — whichever you prefer.

Does this contain caffeine?

No. The "easier mornings, steadier afternoon energy" effect is from mitochondrial cofactors and NAD+ support, not stimulants. Customers often report that they cut their afternoon coffee 4–8 weeks in — that's a downstream signal, not a caffeine effect.

How long until I see something?

For energy and morning quality: typically 2–4 weeks. For nail and hair: 4–8 weeks. For visible skin texture: 8–12 weeks (this matches the published collagen-trial and HA-trial timelines — Proksch 2014, Kawada 2014). Longevity actives (NAD+ pool, mitochondrial cofactors) work silently for the first month before downstream effects compound.

Can I open the capsules and put the powder in a smoothie?

Not recommended. Some of the actives (Vitamin E, NMN, CoQ10) degrade in the presence of light and oxygen — the capsule shell is part of the delivery design. Take the capsules whole.

Is this vegan?

The capsule shell is vegetarian (HPMC, plant-derived). Confirm the full active panel against your dietary needs — full ingredient list is on the supplement-facts panel.

What about cycling — should I take breaks?

The published longevity-trial protocols mostly use continuous daily dosing without cycling. There's no evidence cycling helps. The longevity benefits come from sustained signaling, not pulsed signaling — keep it daily and consistent.

Can men take this?

Yes. Despite the skin/hair language being more often associated with women's products, all five systems in this formula apply to male physiology in the same way — NAD+ decline, mitochondrial decline, antioxidant balance, collagen synthesis (joints, tendons, skin), and HA loss are universal aging biology.

Read more

• What is NAD+? A beginner's guide to the coenzyme behind longevity
• NMN vs NR — which NAD+ precursor actually works better?
• When to take NMN — timing & absorption guide
• Best energy supplements that aren't caffeine
• How to stack longevity supplements — practical protocol for 2026
• True Health Protocols (Cellular Longevity, Beauty & Skin, Fertility, etc.)

Browse the full NAD+ Family: /collections/nad-family · Browse Longevity Essentials: /collections/longevity-essentials

This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the FDA. Consult your physician before starting any supplement, especially if you take prescription medication, are pregnant or breastfeeding, or have a medical condition.