Curcumin 1000mg | 95% Curcuminoids + BioPerine | Anti-Inflammatory Longevity

Curcumin 1000mg with 95% curcuminoids + 5mg BioPerine® — the most-studied anti-inflammatory longevity compound, in the form your body can actually absorb.

The 30-second answer

Curcumin is the active polyphenol in turmeric (Curcuma longa), and it sits at the intersection of two areas modern aging research takes seriously: inflammaging — the slow, tissue-wide simmer of NF-κB-driven inflammation that accumulates with age (Franceschi & Campisi 2014, J Gerontol) — and the endogenous antioxidant system regulated by the Nrf2 transcription factor (glutathione, superoxide dismutase, catalase, heme oxygenase-1). With more than 13,000 peer-reviewed publications on PubMed, including Hewlings & Kalman 2017 (Foods), Aggarwal & Harikumar 2009 (Int J Biochem Cell Biol), Sahebkar 2014 (Phytother Res), Daily 2016 (J Med Food), and Small 2018 (Am J Geriatric Psychiatry), curcumin is one of the few natural compounds that has been shown — in human trials, not just cell culture — to reduce C-reactive protein (CRP), improve joint pain scores comparably to NSAIDs, raise BDNF, and modulate the same molecular pathways targeted by metformin and rapamycin. The catch every supplement taker eventually runs into is bioavailability: Shoba 1998 (Planta Medica) showed that ordinary curcumin reaches plasma at near-undetectable levels because it’s poorly water-soluble and rapidly conjugated in the liver. Co-administering 5mg of piperine (the active in BioPerine®) increased systemic bioavailability by ~2000% in healthy volunteers. This product delivers what the published bioavailability literature actually used: 1000mg of turmeric root extract standardized to 95% curcuminoids plus 5mg BioPerine® at 95% piperine — one capsule, taken with food that contains some fat, once a day.

Why curcumin keeps appearing in serious longevity research

Aging, at the cellular level, is the slow accumulation of low-grade inflammation. The same NF-κB transcription factor that flares when you sprain an ankle stays mildly switched on for decades, driving joint stiffness, cognitive decline, vascular dysfunction, and insulin resistance — what Franceschi & Campisi 2014 (J Gerontol) coined inflammaging. Long-term human cohort data (Framingham, Rotterdam, ARIC) shows elevated CRP, IL-6, and TNF-α are among the most reliable predictors of all-cause mortality and frailty — outpredicting cholesterol in many analyses. Curcumin is one of the few natural polyphenols that has been shown to directly inhibit NF-κB activation at the IκB-kinase step (Singh & Aggarwal 1995, J Biol Chem) and simultaneously activate Nrf2 (Balogun 2003, Biochem J) — the master regulator of the body’s own antioxidant defenses. Most over-the-counter anti-inflammatories suppress symptoms downstream; curcumin works upstream on the signal itself. That dual NF-κB↓ / Nrf2↑ profile is also the reason curcumin shows up alongside resveratrol, fisetin, and quercetin in nearly every published longevity-stack review.

The bioavailability problem — and why BioPerine matters

Curcumin’s biggest failure mode as a supplement is poor absorption. It has low water solubility (about 11ng/mL at physiologic pH), rapid intestinal metabolism, and aggressive hepatic glucuronidation/sulfation. Shoba et al. 1998 (Planta Medica) dosed healthy volunteers with 2g of curcumin alone and measured serum levels at the limit of detection. The same 2g dose plus 20mg piperine raised serum curcumin AUC by ~2000%. The mechanism: piperine inhibits intestinal and hepatic UDP-glucuronosyltransferase, slowing the rate at which curcumin is conjugated and excreted before it reaches circulation. This is why every reputable curcumin product on the market either uses BioPerine®, a phospholipid carrier (Meriva®), a colloidal nanoparticle (Theracurmin®), or a liposomal vehicle — straight 95% curcuminoid powder without a delivery solution is, pharmacokinetically, mostly wasted.

What curcumin actually does — mechanisms in plain English

• NF-κB inhibition. Down-regulates the master inflammation switch that drives chronic disease — specifically by inhibiting IκB kinase (IKK), preventing NF-κB from translocating to the nucleus and switching on TNF-α, IL-1β, IL-6, and COX-2 transcription. Pairs mechanistically with Quercetin (different upstream entry point on the same pathway) and Omega-3 EPA/DHA (resolvin/protectin-driven inflammation resolution).
• Nrf2 activation. Switches on endogenous antioxidant production — glutathione, superoxide dismutase, catalase, heme oxygenase-1 — via Keap1 cysteine modification. Means less dependence on exogenous antioxidants alone. Synergistic with Alpha-Lipoic Acid and NAC.
• Brain / BDNF support. Crosses the blood-brain barrier (one of curcumin’s rare advantages over quercetin and resveratrol). Small 2018 (Am J Geriatric Psychiatry) showed an 18-month Theracurmin trial improved memory-test scores and reduced amyloid/tau PET signal in non-demented older adults. Best framed as long-game cognitive resilience, not nootropic stimulation.
• Joint and tendon comfort. Daily 2016 (J Med Food) meta-analysis of 8 randomized trials in osteoarthritis: 500–1500 mg/day of curcuminoids produced clinically meaningful pain-score reduction comparable to ibuprofen 1200–2400 mg/day, with markedly fewer GI side effects and no anticoagulant burden.
• Cardiovascular markers. Sahebkar 2014 (Phytother Res) meta-analysis: significant CRP reduction (−6.44 mg/L) in adults with elevated baseline inflammation. Endothelial-function trials (Akazawa 2012, Sugawara 2012) show improvements in flow-mediated dilation comparable to moderate aerobic exercise.
• Metabolic / AMPK signaling. Activates AMPK and inhibits mTOR — overlapping with the molecular signature of caloric restriction, metformin, and berberine. Chuengsamarn 2012 (Diabetes Care): 9-month curcuminoid trial in 240 prediabetic adults reduced progression to type 2 diabetes by 100% vs. placebo (16.4% conversion rate in the placebo arm). Pairs naturally with Berberine.
• Senolytic adjacent. Curcumin is not a primary senolytic (that’s Fisetin and Quercetin), but it suppresses the senescence-associated secretory phenotype (SASP) — the inflammatory soup that senescent cells emit before they’re cleared. Curcumin lowers the inflammatory burden of cells you haven’t yet removed.
• Bile and digestive support. Stimulates bile flow (cholagogic). Improves fat digestion. Same mechanism that means people with gallstones should avoid supplemental doses.

The clinical evidence — what published human trials actually showed

References below are listed in full citation form for verification. Curcumin is one of the most extensively studied natural compounds in modern medicine; the trials above are representative, not exhaustive.

Form comparison — what the marketing labels actually mean

For most people running a permanent daily anti-inflammatory layer, 95% curcuminoids + BioPerine hits the sweet spot of clinically meaningful absorption at sustainable cost. Specialty formulations (Meriva, Theracurmin, Longvida) are worth the upcharge when you have a specific need: severe inflammation, gut-absorption issues, or a neuro-focused protocol with brain endpoints in mind.

Where curcumin fits in a longevity stack

Most longevity protocols cover an NAD+ precursor (NMN or NR), a sirtuin activator (Resveratrol or Pterostilbene), and senolytics (Fisetin, Quercetin). What’s missing in 80% of stacks is the inflammation layer — and you can have perfect mitochondrial output, restored NAD+, and cleared senescent cells while still aging fast in a constant low-grade NF-κB simmer. Curcumin is the inflammation-layer cornerstone — same NF-κB endpoint as quercetin, different upstream mechanism, additive in published combination trials, and the only one in the catalog with the brain-penetration data.

Stacking guide — mechanism-organized

• Inflammation layer (the natural pair). Curcumin (NF-κB IKK inhibition) + Quercetin (NF-κB downstream + mast-cell stabilization) + Omega-3 EPA/DHA (resolvin/protectin-driven inflammation resolution). Three different mechanisms converging on the same inflammaging pathway.
• Nrf2 / antioxidant layer. Curcumin + Alpha-Lipoic Acid (recycles Vit C/E/glutathione) + NAC (glutathione precursor) + Glutathione (direct GSH). Curcumin upregulates the system; NAC/glycine/ALA feed the substrates.
• Cardiovascular layer. Curcumin (CRP ↓) + Omega-3 (triglycerides, endothelial function) + Berberine (LDL, glucose) + CoQ10 (mitochondrial energy in cardiac tissue, especially if on a statin).
• Brain / BDNF layer. Curcumin (BDNF, amyloid, tau) + Omega-3 DHA (synaptic membrane fluidity) + Astaxanthin (BBB-crossing antioxidant) + Ashwagandha (HPA-axis / cortisol).
• Senolytic layer (SASP suppression). Curcumin lowers the inflammatory output of senescent cells you haven’t yet cleared, while Fisetin and Quercetin trigger their apoptosis. Curcumin runs daily; senolytics run pulsed.
• AMPK / metabolic layer. Curcumin (AMPK↑, mTOR↓) + Berberine (AMPK↑ via lysosomal mechanism) + Ca-AKG (metabolite, epigenetic clock) — three different upstream entry points to the AMPK/mTOR axis that caloric restriction also targets.
• Joint / connective-tissue layer. Curcumin (NF-κB, prostaglandin signaling) + Collagen peptides (cartilage substrate) + Hyaluronic Acid + Vit C (extracellular matrix support).
• Foundational layer. Curcumin sits in the Foundational Health tier alongside Vitamin D3+K2, Magnesium Glycinate, Omega-3, and Liposomal Vitamin C as a permanent daily, not a pulsed compound.

Where this sits in the catalog architecture

• Foundational tier: Curcumin is one of the seven daily essentials in the Foundational Health protocol — the layer that should be in place before exotic compounds.
• Anti-inflammatory cornerstone: The inflammation-layer counterpart to Quercetin — both NF-κB inhibitors, different upstream mechanisms, additive.
• Cognitive resilience: Member of the Brain & Cognitive stack, alongside Omega-3 DHA and Astaxanthin, by virtue of its blood-brain-barrier penetration and BDNF data.
• Cardiovascular: Member of the Cardiovascular stack via CRP reduction and endothelial-function improvement.
• Joint & connective tissue: Most-clinically-validated daily for joint comfort short of NSAIDs; pairs with collagen peptides and HA.

Why 1000mg specifically

The dose-response curve for curcuminoids in published human trials is fairly well characterized. Below 200mg/day, even with BioPerine, you’re unlikely to see CRP movement. Between 500 and 1000mg/day plus piperine, you sit in the band that produced the CRP, joint-comfort, and metabolic outcomes in Sahebkar 2014, Daily 2016, and Panahi 2017. Above 1500mg/day the marginal benefit plateaus and GI tolerance issues climb. 1000mg of 95% curcuminoids = 950mg active curcuminoids per capsule — right at the modal trial dose, deliverable in a single capsule, with cost-per-day low enough to sustain as a daily for years.

What to expect — week by week

• Week 1–2. Most people notice nothing subjectively. Plasma curcumin steady-state takes about a week to establish.
• Week 2–4. Joint stiffness on waking starts to ease. Post-exercise recovery feels modestly faster. Sleep quality may improve modestly via reduced inflammatory tone.
• Week 4–8. Subjective joint-comfort improvements consolidate; for OA-spectrum users, this is when WOMAC-style pain scores typically drop in trials.
• Week 8–12. Objective markers move — CRP, IL-6, TNF-α if you’re tracking them. Sahebkar 2014 meta-analysis used 8–12 weeks as the typical window for measurable CRP reduction.
• Month 6–18. The cognitive-resilience and cardiovascular-marker territory, per Small 2018 (18 months for memory/PET endpoints) and Akazawa 2012 / Sugawara 2012 (8 weeks for endothelial function, sustained with continued use).
• If you stop: Plasma curcumin is cleared within 24–72 hours; the anti-inflammatory benefit unwinds gradually over 4–8 weeks as NF-κB signaling returns to your previous baseline.

Daily protocol

• Dose: 1 capsule (1000mg curcuminoids + 5mg BioPerine) per day.
• Timing: With a meal that contains some fat — eggs, avocado, olive oil, fish, full-fat yogurt. Curcumin is fat-soluble; the fat improves chylomicron uptake.
• With food: Yes, always. Reduces the small risk of GI upset and improves absorption.
• Duration: Continuous daily — curcumin is treated like fish oil and vitamin D in most longevity protocols, not pulse-dosed.
• Pair with: Quercetin (different NF-κB mechanism), Omega-3 EPA/DHA (resolvin pathway), Vitamin D3+K2 (immune-modulation overlap).
• Bottle: 60 vegetable capsules, 60-day supply at one capsule per day.

Common mistakes to avoid

• Taking curcumin without piperine, phospholipid, or nanoparticle carrier. Most of the dose is wasted — 1g of plain curcuminoids absorbs roughly the same as 50mg with BioPerine.
• Taking curcumin on an empty stomach. Curcumin is fat-soluble; without dietary fat the chylomicron uptake pathway barely engages, and GI tolerance is worse.
• Expecting same-day pain relief. Curcumin works on the underlying signal, not the prostaglandin endpoint. NSAIDs work in hours; curcumin works in weeks. Both work; they’re different timescales.
• Stopping after 2 weeks because “nothing happened.” The Sahebkar 2014 CRP-reduction window is 8–12 weeks; the Daily 2016 joint-comfort window is 4–12 weeks. Curcumin rewards consistency.
• Buying 80% curcuminoid extract because it’s cheaper. 15–20% less active per milligram. The savings disappear once you account for the dose you actually need.
• Pairing with anticoagulants without checking. Curcumin has mild antiplatelet activity. If you’re on warfarin, apixaban, rivaroxaban, dabigatran, or daily aspirin, talk to your prescriber before adding it — not because curcumin is dangerous, but because the cumulative bleeding-time effect should be monitored.
• Continuing through gallbladder symptoms. Curcumin stimulates bile flow. People with active gallstones or biliary obstruction can experience symptoms; stop and see a clinician.

Who this is for

• Anyone running a longevity or healthspan protocol who wants to add the inflammation layer that most stacks miss.
• Adults over 35 with CRP, IL-6, or TNF-α markers in the upper-normal range — the inflammaging audience.
• People with morning joint stiffness, post-exercise inflammation, or osteoarthritis-spectrum symptoms looking for a daily anti-inflammatory that doesn’t carry NSAID GI risk.
• Adults targeting cognitive resilience — particularly with family history of dementia or who want a daily compound with both BDNF and amyloid-clearance signal.
• Statin-users (paired with CoQ10) and prediabetic / metabolic-syndrome adults using curcumin as part of an AMPK / inflammation strategy.

Who this is not for

• Pregnancy or nursing — supplemental doses (above culinary turmeric) are not recommended.
• Active gallstones or biliary tract obstruction — curcumin’s cholagogic effect can provoke symptoms.
• Anyone scheduled for surgery within 2 weeks — stop ahead of elective procedures (mild antiplatelet activity).
• Anyone on warfarin or other anticoagulants without prescriber input.
• Children under 18 (not the population the trials studied).
• Anyone with a known allergy to turmeric or piperine.

Safety and interactions

• Anticoagulants and antiplatelets. Mild additive antiplatelet effect. Talk to your prescriber if you take warfarin, apixaban, rivaroxaban, dabigatran, clopidogrel, or daily aspirin.
• Diabetes medications. Curcumin can mildly improve insulin sensitivity (Chuengsamarn 2012). If you’re on insulin or sulfonylureas, monitor glucose more closely in the first month.
• Iron supplements. Curcumin can chelate iron at high doses. If you have iron-deficiency anemia or take iron, separate by 4+ hours.
• Surgery. Stop 2 weeks before elective procedures.
• GI tolerance. Some people experience mild GI upset on an empty stomach — always take with food. Heartburn is a rare reason to switch to a phospholipid form (Meriva).
• Drug-metabolism interactions. Piperine inhibits CYP3A4. If you take a narrow-therapeutic-index drug metabolized by CYP3A4 (some statins, some calcium-channel blockers, certain immunosuppressants), check with your prescriber.
• Long-term safety. Curcumin has been studied at supplemental doses (up to 8g/day) for 6 months to 2+ years with no serious adverse signal. The 1000mg dose in this product sits well below any reported tolerance threshold.

What’s in it — per capsule

• Turmeric root extract (Curcuma longa) — 1000mg, standardized to 95% curcuminoids = 950mg active curcuminoids (curcumin + demethoxycurcumin + bisdemethoxycurcumin).
• BioPerine® (black pepper extract, Piper nigrum) — 5mg, standardized to 95% piperine. The branded form used in published bioavailability trials.
• HPMC vegetable capsule (vegan).
• Microcrystalline cellulose, vegetable magnesium stearate (flow agents at trace levels).
• No titanium dioxide, no artificial colors, no GMOs, no soy, no gluten, no dairy.
• UV-protective HDPE bottle, 60 capsules — 2-month supply at one capsule per day.

Sourcing, manufacturing, and quality

• Manufactured in a cGMP-certified, ISO 9001-registered facility in the United States.
• Turmeric root sourced from India — the species’ geographic origin and the supply chain with the most established curcuminoid testing infrastructure.
• Per-batch HPLC verification of curcuminoid content (must read ≥95% to ship). Per-batch verification of piperine content in BioPerine.
• Per-batch testing for: heavy metals (lead, cadmium, mercury, arsenic) per USP <2232>, pesticide residues per USP <561>, microbial contamination (total plate count, yeast/mold, E. coli, Salmonella) per USP <2021/2022>, residual solvents per USP <467>, and stability at end-of-shelf-life.
• BioPerine® is the trademarked black pepper extract from Sabinsa Corporation, the formulation used in the majority of published curcumin bioavailability studies, including Shoba 1998.
• COA (Certificate of Analysis) available on request — contact us.

Frequently asked

Why curcumin instead of just eating turmeric? Raw turmeric powder is roughly 3% curcuminoids by weight. To get a 950mg curcuminoid dose from food, you’d need to eat ~32 grams of turmeric powder per day — about 6 tablespoons — and even then, your body would absorb only a tiny fraction without piperine and fat. The extract concentrates the active compound; BioPerine multiplies what reaches your bloodstream.

What does “95% curcuminoids” actually mean? “Curcuminoids” is the umbrella term for three related compounds — curcumin (~75% of the curcuminoid fraction), demethoxycurcumin (~15%), and bisdemethoxycurcumin (~10%) — all of which contribute to the activity. A 95% standardized extract means 95% of the extract by weight is active curcuminoids. Older or cheaper products are often standardized to 80% or unstandardized; per equivalent capsule, that’s 15–20% less active compound.

Why BioPerine and not regular black pepper? BioPerine® is a patented black pepper extract standardized to 95% piperine. It’s the formulation used in the majority of the published curcumin bioavailability studies, including Shoba 1998. Sprinkling pepper on your food gives you maybe 0.1mg of piperine per gram of pepper — not enough to meaningfully shift absorption.

Curcumin + BioPerine vs. liposomal / phytosome / Theracurmin? Specialized formulations like Meriva (phosphatidylcholine), Theracurmin (colloidal nanoparticle), and liposomal curcumin have higher absorption per milligram than curcumin + BioPerine — typically 25–30× for phytosome/colloidal vs. ~20× for BioPerine. They also cost roughly 3–5× as much per dose. For most people running a daily anti-inflammatory base layer, 1000mg curcuminoids + BioPerine delivers a clinically meaningful dose at a sustainable price. If you have specific reasons (severe inflammation, gut absorption issues, neuro-focused protocol), the premium formulations are worth considering.

How long until I notice anything? Subjective markers (joint comfort, post-exercise recovery, mental clarity) — usually 2–6 weeks of consistent daily use. Objective markers (CRP, oxidative stress panels) — 8–12 weeks per the Sahebkar 2014 meta-analysis. Curcumin is a slow-build compound; the goal is the cumulative anti-inflammatory effect, not a same-day pain reliever.

Can I take curcumin long-term? Yes. Curcumin has been studied in human trials for periods of 6 months to 2+ years at doses up to 8 grams/day with no serious safety signal. The 1000mg daily dose in this product is well below any reported tolerance threshold. Most longevity protocols treat curcumin as a permanent daily, like fish oil or vitamin D — not a pulse-dosed compound.

Curcumin vs. ibuprofen? Multiple randomized trials in osteoarthritis have shown comparable pain-score reduction at curcumin doses of 1000–1500mg/day vs. typical NSAID doses (Daily 2016 meta-analysis), with markedly fewer GI side effects and no anticoagulant burden. Curcumin works on the underlying inflammation signal; NSAIDs work on prostaglandin synthesis. They’re not equivalent mechanisms, but the clinical outcome on pain scores is similar over 4–12 weeks.

Curcumin vs. Boswellia, ginger, or other anti-inflammatory botanicals? Different mechanisms. Boswellia inhibits 5-lipoxygenase (leukotriene pathway). Ginger inhibits COX/LOX. Curcumin works upstream on NF-κB / Nrf2 transcription. Stacking is rational and well-tolerated. If you can run only one as a permanent daily, curcumin has the deepest published trial base.

Should I cycle off? Not required. There is no published evidence of curcumin tolerance build-up at supplemental doses. Most longevity protocols run curcumin continuously alongside fish oil and vitamin D as the permanent base of the anti-inflammatory layer.

Why “with food that contains fat”? Curcumin is fat-soluble. Taking it with a fat source increases the fraction that solubilizes into chylomicrons and enters circulation via the lymphatic system — bypassing some of the first-pass hepatic metabolism. This is why curcumin labels recommend taking with a meal, not on an empty stomach.

Why pair with Quercetin if it’s the same NF-κB target? Different upstream mechanisms. Curcumin inhibits IκB-kinase (preventing NF-κB activation). Quercetin acts as a flavonoid antioxidant and mast-cell stabilizer that intersects the same downstream pathway from a different angle. Combination trials show additive (not redundant) effects. They’re frequently stacked in published longevity protocols for this reason.

Yellow staining — is that normal? Yes. Curcumin is the natural yellow pigment in turmeric. If a capsule splits open, the powder will stain — this is purity, not a defect. The same pigment turns Indian curries yellow.

Will curcumin interact with my medications? The interactions worth flagging to your prescriber are: anticoagulants and antiplatelets (mild additive bleeding-time effect), insulin and sulfonylureas (mild glucose-lowering — monitor in month 1), iron supplements (separate by 4+ hours), and CYP3A4-metabolized drugs (BioPerine inhibits CYP3A4 — relevant for some statins, calcium-channel blockers, and certain immunosuppressants). Curcumin itself is not a strong CYP inhibitor; the piperine in BioPerine is the relevant variable.

Is there a CRP threshold below which curcumin doesn’t do anything? The CRP-reduction effect is most pronounced in adults with elevated baseline CRP (above ~3 mg/L). In adults with already-low CRP (under 1 mg/L), the absolute reduction is smaller, but the upstream NF-κB / Nrf2 effects still operate — you’re running the protocol for the next decade’s baseline, not the current week’s blood draw.

Curcumin and depression — is there really an antidepressant signal? Modest but consistent. Lopresti 2014 (J Affect Disord) showed an effect on Inventory of Depressive Symptomatology scores at 500mg BID over 8 weeks in adults with major depression, particularly in the atypical-depression subgroup. The effect size is real but smaller than that of standard antidepressants — curcumin is best framed as adjunctive (in conversation with a clinician), not a primary treatment.

Why is my curcumin dose not bottled with the iron and zinc and other extras some products use? Combination products complicate dose-response and dilute the curcumin per capsule. The published trials used curcumin + piperine alone or curcumin + piperine + a single carrier. We follow that.

Is the BioPerine vegan / GMO-free? BioPerine® from Sabinsa is non-GMO and vegan. The capsule shell is HPMC (cellulose), so the entire product is vegan.

What’s the difference between “turmeric extract” and “curcumin”? Turmeric extract is the broader plant-derived material; curcumin is the specific active polyphenol. A “turmeric extract standardized to 95% curcuminoids” is concentrated extract where 95% of the weight is the active curcuminoid fraction. A label that just says “turmeric” without a standardization percentage is almost certainly raw turmeric powder — the kitchen spice — and a clinical dose would require ~32 grams a day.

Why isn’t curcumin in the senolytics collection? Curcumin suppresses the senescence-associated secretory phenotype (SASP) but doesn’t reliably trigger apoptosis of senescent cells in human-relevant doses. The catalog reserves the “senolytic” tag for compounds with the apoptosis signal — Fisetin and Quercetin. Curcumin is “senolytic-adjacent” — complementary, not duplicative.

Read more on the science

• Inflammaging — the slow inflammatory simmer behind chronic disease
• The Foundational 7 daily nutrients
• The classic longevity stack
• All protocols

Selected references

Shoba G, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64(4):353–356.
Singh S, Aggarwal BB. Activation of transcription factor NF-kappa B is suppressed by curcumin. J Biol Chem. 1995;270(42):24995–25000.
Balogun E, et al. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem J. 2003;371(Pt 3):887–895.
Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent. Int J Biochem Cell Biol. 2009;41(1):40–59.
Akazawa N, et al. Curcumin ingestion and exercise training improve vascular endothelial function. Nutr Res. 2012;32(10):795–799.
Sugawara J, et al. Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women. Am J Hypertens. 2012;25(6):651–656.
Chuengsamarn S, et al. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012;35(11):2121–2127.
Sahebkar A. Are curcuminoids effective C-reactive protein-lowering agents in clinical practice? Phytother Res. 2014;28(5):633–642.
Lopresti AL, et al. Curcumin for the treatment of major depression. J Affect Disord. 2014;167:368–375.
Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69 Suppl 1:S4–S9.
Daily JW, et al. Efficacy of turmeric extracts and curcumin for alleviating the symptoms of joint arthritis: a meta-analysis of randomized clinical trials. J Med Food. 2016;19(8):717–729.
Hewlings SJ, Kalman DS. Curcumin: a review of its effects on human health. Foods. 2017;6(10):92.
Panahi Y, et al. Curcuminoids modify lipid profile in type 2 diabetes mellitus. Drug Res. 2017;67(4):244–251.
Small GW, et al. Memory and brain amyloid and tau effects of a bioavailable form of curcumin in non-demented adults. Am J Geriatr Psychiatry. 2018;26(3):266–277.
Belcaro G, et al. Efficacy and safety of Meriva, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev. 2010;15(4):337–344.
Sasaki H, et al. Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull. 2011;34(5):660–665.
Anand P, et al. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4(6):807–818.
Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15(1):195–218.

References listed in support of mechanism and dose rationale; not as endorsements of off-label medical use. Curcumin and BioPerine are dietary supplements, not pharmaceuticals.

Why not just buy this on Amazon?

You can. Three things are different here. (1) Per-batch HPLC verification of the 95% curcuminoid claim and the 95% piperine claim, with COA available on request — on Amazon you have no idea whether the bottle on the shelf was tested. (2) BioPerine® from Sabinsa, the trademarked black pepper extract used in the original Shoba 1998 bioavailability literature — not a no-name piperine commodity. (3) The catalog architecture — curcumin is positioned, dosed, and stack-mapped against the rest of a longevity protocol you’re likely running, not sold as a one-off SKU.

How to take it

1 capsule once a day, with a meal that contains some fat. Most people take it at breakfast alongside Omega-3 and Vitamin D3+K2 — they’re all fat-soluble and they share the same dosing rule.

Have a question?

Email us at support@truehealthprotocol.health or use the contact page. We answer within one business day.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any new supplement, especially if you take prescription medication, are pregnant or nursing, or have a medical condition.