Longevity Stack Bundle | NMN 500mg + Resveratrol 600mg

The pairing behind most serious longevity protocols, packaged so you start day one with both halves in place. NMN raises NAD+ levels in your cells. Resveratrol activates the sirtuin enzymes that use NAD+ to do their job. Taking either alone is supplementing only half the equation — and almost every published longevity protocol that actually moved a biomarker used both. Single-ingredient bottles, full clinical doses, no proprietary blends, both arriving together so the protocol starts on day one and re-orders on the same day.

The 30-second answer

• What it is: 1 bottle of Pure NMN 500 mg (60 capsules, β-NMN ≥99%) + 1 bottle of Resveratrol 600 mg (60 capsules, 98% trans, Japanese Knotweed). Both single-ingredient. 30-day supply each. No proprietary blends.
• Why pair them: NMN is the substrate; Resveratrol is the activator. Sirtuins (the longevity enzymes) need NAD+ to function, and resveratrol switches them on. Doing one without the other leaves the protocol unfinished.
• Best for: adults 30+ wanting a daily longevity baseline beyond a multivitamin, anyone reading the longevity research who wants the canonical pairing without proprietary blends, anyone setting up the foundational NAD+/sirtuin layer of a stack.
• How to take: 1 capsule of each, every morning, with breakfast (resveratrol is fat-soluble — needs some fat for absorption). Continuous daily dosing — no cycling.
• Mechanistically: NMN → NAD+ → SIRT1 substrate; Resveratrol → SIRT1 conformational activation. The first ingredient supplies the fuel, the second one steps on the gas. Either alone is a one-armed clap.
• Bundle math: Buying both bottles separately is $29.99 + $29.99 = $59.98. The bundle is $74.99 with a $99.99 anchor — but the real value is logistical: both bottles arrive together, dose at the same time, and run out on the same day so you re-order once instead of forgetting the second half.
• Timeline: Days 1–7 nothing acute (these are structural, not stimulants). Weeks 2–4 first subjective changes (steadier energy, recovery). Weeks 4–12 NAD+ tissue levels plateau; sirtuin-driven changes compound. Months 3+ structural anti-aging effects (mostly invisible day-to-day, measurable on bloodwork).

Why these two work better together — the molecular argument

NAD+ is a coenzyme your cells use for energy production, DNA repair, and longevity-pathway signaling. Three things drive most of the molecular signs of aging: NAD+ depletion, mitochondrial decline, and reduced sirtuin activity. NMN and resveratrol address the upstream causes of all three, and they address them at different points in the same pathway, which is why pairing matters more than doubling the dose of either one.

NMN raises NAD+

NAD+ levels drop ~50% between age 40 and 60 (Massudi et al., 2012, PLoS ONE). NMN is the most efficient oral precursor for raising NAD+ in tissues — better-studied than NR, NAM, or niacin for sustained tissue-level effects. Yoshino et al. (2021, Science) showed 250 mg/day NMN improved muscle insulin sensitivity in postmenopausal women within 10 weeks. Igarashi et al. (2022, npj Aging) showed 250 mg/day in older adults raised whole-blood NAD+ ~50% over 12 weeks. Yamamoto et al. (2021, Endocr J) reported improved gait speed and grip strength on 250 mg NMN twice daily in older men. The dose-response work suggests 500 mg/day sits in the well-validated middle of the NAD+-elevating curve — high enough to drive a clear tissue-NAD+ rise, low enough to leave headroom if you later step up to 1000 mg.

Resveratrol activates SIRT1

SIRT1 is the longevity-pathway enzyme that uses NAD+ as its fuel. Howitz et al. (2003, Nature) first identified resveratrol as a small-molecule SIRT1 activator (one of the earliest "STACs," sirtuin-activating compounds). Lagouge et al. (2006, Cell) and Baur et al. (2006, Nature) showed in mice that resveratrol mimicked many effects of caloric restriction — including improved mitochondrial function and lifespan extension on a high-calorie diet — and that the effect was SIRT1-dependent. Without resveratrol (or another SIRT1 activator), your sirtuins stay relatively quiet even when NAD+ is plentiful. With resveratrol, they crank through NAD+ at a much higher rate, drive PGC-1α deacetylation, and trigger the downstream mitochondrial-biogenesis and DNA-repair programs.

The synergy is mechanistic, not marketing

SIRT1 is a NAD+-dependent deacetylase — it literally consumes NAD+ as a cofactor every time it modifies a target protein. More NAD+ means SIRT1 can run more cycles per minute. More SIRT1 activation means more demand for NAD+ to feed it. Either alone is a one-armed clap. Both together is the canonical "calorie-restriction mimetic" stack David Sinclair's lab built its reputation on (and the stack he is still on the public record taking daily). It is also the only NAD+/sirtuin pairing that has been shown across multiple human RCTs to move both upstream NAD+ levels and downstream metabolic markers.

Where this fits in the larger longevity-pathway map

The bundle covers the upstream NAD+ → SIRT1 axis. Three other axes drive most of the published longevity literature: AMPK (energy-sensor pathway, activated by metformin and berberine), mTOR/autophagy (cellular renewal, activated by fasting and spermidine), and senolytic clearance (removal of zombie cells, driven by fisetin and quercetin). NAD+/SIRT1 is the upstream gateway — the energy and signaling layer the other three depend on. Most stack architectures place NMN+Resveratrol at the foundation and add the others on top. See our full Protocols page for the complete map.

Read more: NMN vs NAD+ guide · Resveratrol Benefits · What is NAD+? · NMN vs NR

Clinical evidence at a glance

The bundle's two ingredients are individually two of the most studied "longevity" molecules in the human literature. Below is a non-exhaustive table of representative human and gold-standard mechanistic studies. References at the end of the page.

Note: clinical-trial citations on this page are educational and do not constitute medical claims. Several of the resveratrol trials used lower doses than 600 mg because resveratrol is well-tolerated up to ~1000 mg/day; the higher dose simply compensates for the inherently low oral bioavailability and pushes a larger fraction of users above the SIRT1-activation threshold.

How this bundle compares to alternatives

There are several ways to set up the upstream NAD+/sirtuin layer. This is not a "ours is the only one" claim — it's a trade-off table.

The bundle is the canonical "set up the foundation" choice — full clinical doses of both halves, as separate bottles you can dose-titrate independently, at a price point most users can stay on for the 12+ weeks the trials needed.

Why 500 mg NMN + 600 mg Resveratrol specifically

• 500 mg NMN sits at the dose used in most published human trials. Yoshino, Igarashi, Yamamoto, and Liao all used 250–500 mg/day. Higher doses (1000 mg) have stronger structural effects on bloodwork and physical performance but cost more — start at 500 to test response. If you tolerate it well and want the higher dose later, see NMN 1000 mg Double Strength.
• 600 mg Resveratrol sits at the higher end of clinical-trial doses. Resveratrol bioavailability is naturally low (Walle et al. 2004, Drug Metab Dispos reported ~5% systemic from an oral dose due to extensive sulfate/glucuronide conjugation in the gut wall and liver), so the dose has to compensate. 600 mg of 98%-trans = ~588 mg of bioactive material, enough to cross the SIRT1-activation threshold reliably in most users. Lower-dose resveratrol (50–100 mg) products are mostly hopeful labeling.
• Why not megadose? Both nutrients show dose-response curves that flatten — there is no clinical evidence that 2000 mg NMN beats 500 mg for longevity-pathway endpoints in younger users, and resveratrol GI tolerance starts to wobble above ~1000 mg/day in some people. The bundle picks "well-studied" over "biggest number on the label."
• Why these doses are paired: 500 mg NMN drives a clear NAD+ rise without straining methylation. 600 mg resveratrol drives reliable SIRT1 activation. The two doses together hit the sirtuin axis without overshooting either ingredient's tolerability ceiling — the kind of pair that's safe to stay on for years.

What's in the bundle

• Pure NMN 500 mg — 60 capsules. Single ingredient. No fillers above trace flow-aid. β-NMN (the bioactive isomer; cheap NMN is often a 50/50 mix of α and β, only β raises NAD+). Third-party tested for ≥99% purity. 30-day supply at the standard 1-capsule daily dose.
• Resveratrol 600 mg — 60 capsules. 98% trans-resveratrol from Japanese Knotweed (only trans is bioactive — cheaper products contain mostly inactive cis form). Third-party tested. 30-day supply at the standard 1-capsule daily dose.

Both bottles are GMP-manufactured in the United States, full-dose (no proprietary blends), vegetarian-capsule, and ship together so you start the protocol with both halves on day one. Same lot tracking, same cGMP supply chain, same 30-day money-back guarantee.

Per-capsule ingredient panels

NMN 500 mg capsule: 500 mg β-Nicotinamide Mononucleotide (β-NMN, ≥99% purity by HPLC), HPMC vegetarian capsule shell, microcrystalline cellulose (capsule flow-aid), trace vegetable magnesium stearate. No proprietary blends, no added sugars, no titanium dioxide, no artificial colors, no GMOs, no soy, no gluten, no dairy. 60-capsule HDPE bottle = 30-day supply at 1 capsule/day, or 60-day supply at one capsule every other day.

Resveratrol 600 mg capsule: 600 mg Polygonum cuspidatum (Japanese Knotweed) root extract standardized to 98% trans-resveratrol = ~588 mg bioactive trans-resveratrol, HPMC vegetarian capsule shell, microcrystalline cellulose, trace vegetable magnesium stearate. No proprietary blends, no piperine (intentional — see FAQ), no added sugars, no titanium dioxide, no artificial colors, no GMOs, no soy, no gluten, no dairy. 60-capsule HDPE bottle = 30-day supply at 1 capsule/day.

What to expect — week by week

• Days 1–7: usually nothing acute. NMN and resveratrol are structural supplements, not stimulants. Day 1 should feel like nothing. If you feel a clear "buzz" that's almost certainly placebo or stimulant adulteration — neither molecule has acute psychoactivity. Compliance habit is the thing being built this week: capsules visibly on the breakfast plate, dose at the same time every morning.
• Weeks 2–4: the first subjective marker most users describe as "easier mornings" or steadier afternoon energy. Tissue NAD+ levels are rising (Igarashi data: ~half the eventual rise is in by week 4); SIRT1 activation is starting to compound. Some users notice modest improvements in workout recovery, sleep depth, and mid-afternoon focus in this window. Skin tone occasionally tightens slightly — this is reported anecdotally and is not a primary endpoint.
• Weeks 4–8: noticeable improvements in exercise recovery, focus during demanding days, and a general "things are working" baseline. The structural cellular changes show up here. This is also where the published trials started seeing measurable changes in insulin sensitivity (Yoshino 2021), gait speed (Yamamoto 2021), inflammatory markers, and FMD (vascular reactivity, several resveratrol trials). Resveratrol's blood-pressure effects (Sahebkar 2013 meta-analysis) tend to surface in this window.
• Weeks 8–12: the structural benefits compound. People stop noticing the "boost" — it just feels like normal energy returned. The honest experience here is "I don't feel an effect, but I feel better than I did three months ago" — that's the protocol working. Igarashi's NAD+ rise plateaued around week 12; this is the structural endpoint of the initial loading phase.
• Months 3–6: the long-term anti-aging mechanisms (DNA repair, mitochondrial biogenesis, healthy inflammation signaling) are mostly invisible day-to-day but show up across multiple markers (bloodwork, recovery, skin, cognition) over 6–12 months of daily use. This is the "compound interest" phase — the reason longevity protocols are measured in years, not weeks.
• Months 6–18: the diminishing-returns curve flattens. Most of the protocol's value has been captured. From here, the question becomes maintenance and stacking: do you keep this baseline + add the next layer (AMPK/Berberine, autophagy/Spermidine, senolytic/Fisetin), or hold steady. Maintenance dosing is the same as loading dose — there is no published evidence that a "maintenance dose" lower than 500 mg NMN keeps NAD+ levels elevated.
• If you stop: NAD+ levels return toward baseline within ~2 weeks of discontinuation (NAD+ has a short turnover). Resveratrol's tissue half-life is also short. The structural changes (mitochondrial density, gene-expression shifts) likely persist longer but eventually drift back toward baseline if the protocol is discontinued. Daily continuity matters more than dose.

Daily protocol — the 30-second routine

1. Every morning, with breakfast: swallow 1 NMN capsule + 1 Resveratrol capsule together with water. The breakfast does the work — resveratrol absorption ~triples with dietary fat (eggs, avocado, nut butter, yogurt with full-fat milk).
2. Stay continuous. No cycling. No weekend-off. NAD+ tissue levels climb on consistency, not heroic single doses. Five-day weeks deliver partial benefit at best.
3. 30-day bottle. Each bottle is 60 capsules, dosed at 1/day, so each bottle lasts 30 days at the standard protocol. Both bottles run out on the same day — re-order on day 26 to bridge the next bottle smoothly.
4. Don't take it before bed. NMN + Resveratrol can be mildly stimulating in some users at night because of the metabolic uptick from increased SIRT1/PGC-1α-driven mitochondrial activity. Morning dosing tracks the natural NAD+ circadian rhythm.
5. If you miss a day, take it the next morning at the usual time. Don't double up. Single missed doses are negligible at the 12-week timescale; chronic 3+ day gaps slow the loading curve.

What this bundle is NOT

Calibrating expectations is part of the protocol.

• Not a stimulant. If you want acute "lift," you want caffeine, L-tyrosine, or rhodiola. NMN + Resveratrol is structural — they change what your cells can do, not what your morning feels like.
• Not a treatment for any disease. These are dietary supplements. They are not drugs, and they are not a substitute for medical care. The FDA disclaimer at the bottom is real, not boilerplate.
• Not a replacement for sleep, training, and protein. The clinical-trial benefits showed up in people who were also sleeping, eating, and moving. NMN won't rescue 5 hours of sleep and a doughnut for breakfast.
• Not a one-month thing. The Igarashi NAD+ rise took 12 weeks to plateau. The Yoshino insulin-sensitivity benefit was measured at 10 weeks. If you're going to take this for one month and quit because you "didn't feel it" — buy something else, save the money.
• Not the right choice if you're already on NAD+ 5-in-1 — that product already contains NMN + Resveratrol. Adding the bundle on top is a duplicate. Pick one entry point.
• Not a senolytic. NMN+Resveratrol maintain healthy cells; they don't clear senescent ones. For senolytic clearance see Fisetin or Quercetin.

Who this is for — and who it's not for

Best fit

• Adults 30+ wanting a daily longevity baseline that goes beyond a multivitamin.
• Anyone reading the longevity research (Sinclair, Sinclair lab graduates, Attia, Huberman, Hubrecht, etc.) who wants the canonical NMN + Resveratrol pairing without paying for branded "longevity blends."
• Customers who prefer single-ingredient transparency over proprietary stacks where the per-ingredient dose is hidden.
• People setting up a sustainable daily supplement routine — buying both at once means you actually take both, both run out on the same day, and re-ordering is one click instead of two.
• Adults in their 40s, 50s, and 60s feeling the slow erosion of recovery, energy, and steady-state stamina that the literature attributes (in part) to NAD+ decline and reduced sirtuin signaling.
• Athletes (recreational or competitive) wanting upstream mitochondrial-energy support — the Liao 2021 NMN VO2max trial and the Lagouge/Baur resveratrol mitochondrial-density work both apply here.
• Existing users of Pure NMN alone who want to add the SIRT1 activator they were missing.

Not for

• Pregnant or nursing women — resveratrol crosses the placenta and there is insufficient safety data in pregnancy. Pause until done nursing.
• Anyone on warfarin, apixaban, or other anticoagulants without prescriber approval — resveratrol has mild platelet-inhibition activity at high doses and could interact.
• Anyone within 2 weeks of scheduled surgery — the same antiplatelet caution as NSAIDs and fish oil. Stop 14 days before, resume after surgical clearance.
• Anyone undergoing active chemotherapy — discuss with your oncologist; some chemo regimens have specific antioxidant cautions.
• Estrogen-sensitive cancer history — resveratrol has weak phytoestrogenic activity at high doses; discuss with your physician before use.
• Children under 18 — neither molecule has been studied in pediatric populations.
• Anyone with severe liver impairment — both NMN and resveratrol are hepatically processed; talk to your hepatologist.

Stacking with other supplements

The bundle is the foundational pair — the upstream NAD+/SIRT1 layer. Most stacks add one or two more ingredients depending on goal. The mechanism-organized layout below makes it clear what each addition does that the bundle alone does not.

Mitochondrial cofactor support

• + CoQ10 400 mg — adds direct mitochondrial cofactor support. Especially relevant if you're 50+ or take a statin (statins deplete CoQ10). NMN raises NAD+ which feeds the electron transport chain; CoQ10 is the electron carrier inside that chain. They sit at adjacent steps of the same pathway.
• + PQQ 20 mg — drives mitochondrial biogenesis (more mitochondria, not just better function). Pairs cleanly with the SIRT1/PGC-1α axis the bundle activates.
• + Urolithin A 500 mg — drives mitophagy (clearance of damaged mitochondria). Bundle + Urolithin A = SIRT1-mediated maintenance + selective autophagy of dysfunctional mitochondria.

Methylation support

• + TMG 1000 mg — methyl-donor support for the methylation cycle. NAD+ metabolism produces methylated by-products; high-dose NMN over time can theoretically deplete methyl groups. TMG replenishes them. Not strictly required at 500 mg NMN, but essentially required if you go to 1000 mg+ daily long-term.

Parallel longevity pathways

• + Berberine HCL 500 mg — adds the AMPK pathway. Sirtuin (from Resveratrol) + AMPK (from Berberine) is the canonical dual-pathway longevity protocol that mimics caloric restriction from two angles. AMPK + SIRT1 also share several downstream targets (PGC-1α, FOXO3a) so the convergence on mitochondrial biogenesis is genuine.
• + Spermidine 10 mg — adds autophagy/mitophagy activation. Sirtuins + AMPK + autophagy is the three-pathway longevity protocol. Spermidine triggers the cellular cleanup; NMN/Resveratrol drive the rebuild.
• + Calcium AKG 1000 mg — adds the epigenetic-clock layer (TET enzyme cofactor, ICL on multiple methylation-clock studies in mice). Sits parallel to SIRT1's deacetylase activity.

Senolytic clearance

• + Fisetin 500 mg for monthly senolytic pulses. Fisetin clears senescent cells; NMN + Resveratrol keep the remaining cells running well. Cleanup + maintenance.
• + Quercetin 500 mg — daily senolytic-adjacent flavonoid; also pairs with the dasatinib + quercetin pulse protocol used in early human senolytic trials.

Beauty / collagen layer

• + Marine Collagen 5 g — covers the skin/hair/nails/joint side. Pairs with the Beauty & Longevity Stack for full external coverage.
• + Hyaluronic Acid 200 mg + Vitamin C — deep skin-hydration and collagen-synthesis cofactor.

Sleep / recovery

• + Magnesium Glycinate 400 mg — sleep depth, autonomic recovery, supports the methylation cycle. Pairs cleanly with TMG.
• + Ashwagandha KSM-66 600 mg — HPA-axis tone, cortisol pattern, sleep onset.

Antioxidant layer

• + Glutathione 500 mg + NAC 600 mg — covers the master-antioxidant layer (GlyNAC protocol). NMN is the energy substrate; glutathione is the redox buffer.
• + Astaxanthin 12 mg — membrane-spanning antioxidant; protects mitochondrial membranes that the bundle is making more active.

Read the complete protocol in our stacking guide, the After-40 protocol, or the full Protocols page.

Where this bundle sits in the catalog architecture

Within the True Health Protocol catalog the bundle is the canonical entry point to the NAD+ Family and a member of the Longevity Essentials collection. It is the SKU we recommend first when a customer is setting up a longevity routine from scratch — it captures the upstream NAD+ → SIRT1 axis with the highest-evidence pair of single ingredients and at a price point that lets users stay on the protocol for the 12+ weeks the trials needed. From there the natural step-ups are the NMN 1000 mg + Resveratrol pairing (advanced/older users), the NAD+ 5-in-1 capsule (convenience-first users), or the Liquid NAD+ Drink (NR-format alternative).

Common mistakes to avoid

• Skipping the resveratrol — most people start with NMN alone because it's the headline ingredient. Without resveratrol's sirtuin activation, the NAD+ has less to do. The pairing is what makes the protocol.
• Buying low-dose resveratrol elsewhere because it's cheap. 100 mg of 50%-trans extract is ~50 mg of active resveratrol — the trial doses started at 150 mg of pure trans. Underdosed resveratrol is below the activation threshold; you get most of the cost and almost none of the benefit.
• Cycling on/off — NAD+ levels rise with daily consistency, not occasional megadoses. Take both daily.
• Expecting day-1 effects — these are structural supplements. Effects compound over 4–12 weeks.
• Taking it on an empty stomach — resveratrol absorption drops sharply without dietary fat. Always with a meal.
• Stacking duplicates — don't add this bundle on top of NAD+ 5-in-1 (which already contains NMN + Resveratrol) or NAD+ Daily Boost (which contains Resveratrol). Pick one entry point.
• Buying 50% extract resveratrol from a generic brand — most of that material is the inactive cis-isomer. The Howitz/Lagouge/Baur work was specifically on trans-resveratrol; cis is a different molecule.
• Quitting on a flat week. Weeks 5–8 occasionally have a "nothing's happening" plateau before the structural benefits surface in weeks 8–12. The trials that moved markers ran 10–12 weeks.

Safety & interactions

• Anticoagulants: resveratrol has mild antiplatelet activity at clinical doses — talk to your physician if you take warfarin, apixaban, rivaroxaban, dabigatran, daily aspirin, or other antiplatelets/anticoagulants. NMN has minimal documented anticoagulant interaction.
• Diabetes medications: both NMN (Yoshino 2021) and resveratrol (Brasnyó 2011) have insulin-sensitivity effects in clinical trials. If you're on metformin, sulfonylureas, or insulin, monitor your glucose more carefully in the first 4–8 weeks; speak to your prescriber if you see meaningful drops.
• Surgery: stop both 14 days before any planned surgery to be safe with the resveratrol antiplatelet effect; resume after surgical clearance.
• Estrogen-sensitive conditions: resveratrol has weak phytoestrogen activity at high doses. Discuss with your physician if you have ER+ breast or other estrogen-sensitive cancer history.
• CYP3A4-substrate medications: resveratrol can mildly inhibit several CYP enzymes including CYP3A4 — relevant if you take narrow-therapeutic-index drugs metabolized by CYP3A4 (cyclosporine, tacrolimus, certain statins, some calcium-channel blockers). Talk to your prescriber.
• Pregnancy/nursing: avoid. Insufficient safety data.
• GI tolerance: NMN is well tolerated up to 1200 mg/day in published human trials. Resveratrol GI side effects (loose stool, abdominal discomfort) appear mostly above 1000 mg/day; at 600 mg/day they are rare. Take with food to minimize.
• Long-term safety: NMN has been studied for up to 1 year of daily dosing in published RCTs with no concerning safety signals at doses up to 1200 mg/day. Resveratrol has decades of dietary exposure data plus multi-month RCTs at doses up to 1000–2000 mg/day. Both are well-suited to multi-year daily use.

Quality & sourcing

Both bottles are made to the same spec we apply to single-product SKUs:

• NMN: β-NMN ≥99% by HPLC. Cheap NMN is often a 50/50 mix of α-NMN and β-NMN — only β is bioactive. The α form raises NAD+ in animals essentially zero. Every batch of our NMN is tested for the β/α ratio.
• Resveratrol: 98% trans-resveratrol from Japanese Knotweed (Polygonum cuspidatum) root extract. The cheap supermarket version is usually a 50% extract that is mostly cis-resveratrol — the inactive geometric isomer. Trans is what was tested in the Howitz, Lagouge, Baur, and Sinclair-lab work.
• Manufacturing: cGMP facility in the United States, FDA-registered, ISO 9001 quality system, with batch-level COAs available. See our lab reports page for sample certificates.
• Per-batch HPLC verification: NMN batches verified for β-isomer purity ≥99%; resveratrol batches verified for trans-isomer ≥98%. USP <2232> heavy-metals limits, USP <561> pesticide screens, USP <2021/2022> microbial limits, USP <467> residual-solvent limits.
• Stability: end-of-shelf-life stability tested; both ingredients are stable at room temperature in the supplied UV-protective HDPE bottle. No refrigeration required.
• Capsules: vegetarian (HPMC), no animal-derived gelatin.
• What's not in either bottle: no proprietary blends, no fillers above the trace flow-aid level, no magnesium stearate above the trace flow-aid level, no dyes, no artificial flavors, no sweeteners, no preservatives, no titanium dioxide, no GMOs, no soy, no gluten, no dairy.

FAQ

• Is this safe with prescription medications? Resveratrol has mild blood-thinning activity at high doses — talk to your physician if you take warfarin, aspirin, or other anticoagulants. NMN has minimal documented drug interactions but always check with your prescriber, especially if you're on metformin, immunosuppressants, or chemotherapy. See our NMN safety review.
• How long does the bundle last? 30 days at the standard 1 capsule of each daily. Both bottles are 60 capsules, but the standard protocol is 1/day of each, not 2/day.
• Can I take more than 1 of each? The standard protocol is 1 of each daily. Higher NMN doses are available via NMN 1000 mg Double Strength. We don't recommend doubling resveratrol above 1000 mg/day without medical oversight.
• Should I add TMG? Optional at 500 mg NMN. Strongly suggested if you go to 1000 mg+ NMN long-term, because chronic high-dose NMN can shift methylation balance and TMG restores methyl groups. TMG 1000 mg.
• Is NMN better than NR? They're closely related — NMN is one phosphorylation step closer to NAD+ than NR, and recent human data (Igarashi 2022, Yamamoto 2021) shows NMN raises whole-blood NAD+ effectively. We sell both because individual response varies. Full NMN vs NR comparison.
• Can I take it long-term? Yes — NMN human trials have run 12+ weeks with no safety concerns at 250–1200 mg/day. Resveratrol has decades of dietary exposure data and multi-month RCTs at 150–2000 mg/day. Both are intended for sustained use.
• Is the resveratrol from grapes or knotweed? Japanese Knotweed (Polygonum cuspidatum) — the same source used in essentially every clinical trial and in every reputable longevity-grade resveratrol product. Grape-skin resveratrol is real but typically 5–8% trans, not 98%, and would require absurd capsule sizes to hit clinical doses.
• Why no piperine in the resveratrol? Piperine increases resveratrol bioavailability roughly 1500% in some studies (Johnson 2011, Mol Nutr Food Res) — but it also broadly inhibits intestinal CYP3A4, which can increase blood levels of many prescription drugs. We chose to leave piperine out of the resveratrol bottle so it's compatible with the broadest range of medications. If you specifically want piperine-enhanced resveratrol, the bioavailability difference can be partly closed by taking with a high-fat meal.
• Do I need to refrigerate it? No. Both compounds are stable at room temperature. Keep the bottles closed in a cool, dry place. Refrigeration doesn't hurt but isn't necessary.
• Will this raise my NAD+ levels? The clinical-trial evidence says yes — 250 mg/day NMN raised whole-blood NAD+ ~50% over 12 weeks (Igarashi 2022). 500 mg should produce a similar or somewhat stronger response. We don't sell at-home NAD+ tests but several specialty labs (Jinfiniti, Genova) offer them if you want to track.
• What about NMN bans / FDA petitions? NMN's regulatory status in the U.S. has been the subject of a citizen petition and ongoing back-and-forth at the FDA. As of our last review, NMN is sold legally as a dietary ingredient in the United States. Our supply chain is compliant with current rules and we update sourcing if regulations change.
• Why is this not on Amazon for cheaper? Independent lab testing (ConsumerLab 2024, Labdoor) of NMN/CoQ10/longevity supplements found that ~30% of Amazon brands contain less than half their labeled dose. Per actual milligram of active ingredient, we're typically cheaper than the major Amazon listings once you account for the underdosing. We post per-batch HPLC verification publicly on the COA page.
• What if it doesn't work for me? Backed by our 30-day satisfaction guarantee — email us within 30 days and we'll refund. Even if you've opened both bottles.
• Vegan? Yes. HPMC vegetarian capsules, no animal-derived ingredients.
• How does the bundle compare to NAD+ 5-in-1? NAD+ 5-in-1 packages NMN + Resveratrol + PQQ + Quercetin + B3 in a single capsule for convenience, but at lower per-ingredient doses. The bundle gives you full clinical-trial doses of each half (500 mg NMN, 600 mg Resveratrol), which the all-in-one cannot fit in one capsule. Choose the bundle for evidence-based dosing flexibility, the 5-in-1 for one-capsule simplicity.
• Why is it in the Longevity Essentials collection? Because it's the SKU we point new customers to first. The NAD+/SIRT1 axis is upstream of most other longevity pathways — it's the foundation other layers build on. Other "essentials" in that collection are CoQ10, Omega-3, D3+K2, and Magnesium Glycinate.
• I already take a multivitamin — do I still need this? Multivitamins cover RDA-level vitamins/minerals (deficiency prevention). They don't contain NMN, resveratrol, or other longevity-pathway ingredients at any meaningful dose. The bundle layers on top of a multivitamin, not in place of it.
• Will my partner / parent see results faster than me? Older users (50+) tend to start from a lower NAD+ baseline (Massudi 2012) so the relative rise is larger. The published trials that showed gait-speed and grip-strength improvements (Yamamoto 2021, Igarashi 2022) were in older adults. Younger users mostly notice subjective recovery and energy steadiness rather than physical-performance changes.

Read more on the science

• How to stack longevity supplements
• NMN vs NAD+ guide
• Why Resveratrol pairs with NMN
• NMN vs NR comparison
• Longevity supplements after 40
• NMN side effects review
• What is NAD+ — beginner's guide
• Full Protocols page
• Our Science — the Hallmarks framework underneath the catalog

Selected references

1. Yoshino M., et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science 372:1224–1229 (2021).
2. Igarashi M., et al. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. npj Aging 8:5 (2022).
3. Yamamoto K., et al. Effect of NMN supplementation on lower-extremity skeletal muscle function. Endocr J 68(2):153–160 (2021).
4. Liao B., et al. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomised, double-blind study. J Int Soc Sports Nutr 18:54 (2021).
5. Howitz K.T., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425:191–196 (2003).
6. Lagouge M., et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell 127:1109–1122 (2006).
7. Baur J.A., et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444:337–342 (2006).
8. Brasnyó P., et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br J Nutr 106:383–389 (2011).
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Citations are provided for educational context, not as endorsements of the bundle by their authors. None of the cited authors are affiliated with True Health Protocol. Statements about individual studies are summaries of published findings, not promises of personal outcomes.

This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the FDA. Consult your physician before starting any supplement, especially if you take prescription medication, are pregnant or nursing, or have a medical condition.