About True Health Protocol

About True Health Protocol

A founder-led longevity supplement brand built around clinical-trial doses, bioavailable forms, third-party-verified actives, and a deliberately narrow catalog mapped to the 12 Hallmarks of Aging framework.

The 60-second version

• What this brand is. True Health Protocol formulates and ships a focused catalog of longevity and rejuvenation supplements — NAD+ precursors, sirtuin activators, senolytics, mitochondrial actives, methyl donors, foundational nutrients, and the beauty/skin/connective layer — built around the pathways the peer-reviewed literature has converged on.
• Why it exists. Most retail supplements are formulated around margin and marketing, not mechanism — fairy-dust doses, cheap forms of the right molecule, proprietary blends that hide how little active is actually inside, and "supports cellular health" wording that sounds meaningful and isn't. We refuse all six of those tricks. The full breakdown is below in The pattern in the industry.
• How we formulate. Five rules — clinical-trial doses, bioavailable forms by default, single-actives where the evidence is single-active, stacks where the evidence is stack-based, and no ingredient gets in without a mechanism. Every active maps to at least one Hallmark of Aging per López-Otín 2013/2023.
• How we source. Three-tier verification (HPLC identity + ≥90% potency, ICP-MS heavy metals against Cal Prop 65 daily limits, USP microbial / pesticide / residual solvent screens), branded raws where the trials used a branded raw (KSM-66, BioPerine, TRAACS, MK-7 from natto), country-of-origin transparency on every active. Per-batch CoAs available on request.
• What's in the catalog. 40 active SKUs across 18 collections — anchored by 13 smart collections (Foundational Health, NAD+ Family, NMN, Senolytics, Mitochondrial Renewal, Cardiovascular, Brain & Cognitive, Antioxidants, Collagen, Metabolic, Fertility, Most Popular, All Products) and 5 curated bundles (Starter Bundles, Longevity Essentials, Beauty & Anti-Aging, Skin Protocol, Top Picks).
• What backs the purchase. A real 30-day money-back guarantee — opened or unopened, no restocking fee, no quiz, original shipping refunded. Detailed at /pages/guarantee.
• Where we are in the lifecycle. Founder-led, privately held, no outside capital pushing for hyper-growth shortcuts. We add a SKU when the evidence is strong enough, not when the trend is. We say no to ingredients we can't defend mechanistically.
• What we're not. Not a multivitamin company. Not a TikTok-trend chaser. Not a private-label reseller of Amazon SKUs. Not your physician. Statements on this site have not been evaluated by the FDA; our products are not intended to diagnose, treat, cure, or prevent any disease.

On this page

• Why this brand exists — the personal problem
• The pattern in the industry — and what we refuse to do
• What we actually do
• Our five formulation rules
• How we source and manufacture
• Manufacturing partners and the supply chain you'll see on a product page
• What we won't do
• Who this catalog is built for
• Catalog at a glance — by Hallmark, by goal, by onboarding tier
• Three reading paths through the brand
• The 30-day guarantee, in plain English
• How we treat support
• A note from the founder
• Brand commitments — the operational checklist
• How this brand got here — a short timeline
• Where to start
• FAQ — about the brand
• Reading list — go deeper
• Selected primary references
• How we revise this page

Why this brand exists — the personal problem

This started as a personal problem. Years of reading research — actual studies, not summaries — made it impossible to walk into a supplement store without becoming frustrated. The dosages were wrong. The forms were cheap. The ingredient lists were built to impress at a glance, not to function. A supplement with 10mg of ashwagandha in it isn't an ashwagandha supplement. It's a label claim.

The more research one did, the clearer the pattern became: most supplements are formulated around margin and marketing, not mechanism. The active ingredient dose gets cut to make room for six other ingredients on the label. Cheap forms get used because they're cheaper, not because they work. "Proprietary blend" means you're not allowed to know how little of the thing that matters is actually in the capsule.

True Health Protocol was built as a direct response to that. Every formula starts with the research question — what does the peer-reviewed literature say this ingredient needs to do, at what dose, in what form — and works backwards from there. If the human trials on berberine use 500mg three-times-daily for 12 weeks (Yin 2008 Metabolism; Lan 2015 27-RCT 2,569-patient meta-analysis), that's the dose anchor in the capsule. If the evidence on NAD+ precursors supports liposomal delivery for direct NAD+ (vs. precursor-only oral), that's what gets developed. If there's no strong evidence for an ingredient, it doesn't make the formula — regardless of how well it sells, regardless of how many TikToks ran on it last quarter, regardless of how cheap the raw material is.

That stance is a deliberate choice. There are easier ways to run a supplement company. The catalog could be five times the size if the rule were "list any ingredient with at least one mouse study and a willingness to use a proprietary blend." We'd rather move slowly, ship a small number of formulas the team is willing to put their names on, and let the catalog earn trust the way it ships — one transparent dose, one bioavailable form, one peer-reviewed mechanism at a time.

The pattern in the industry — and what we refuse to do

If you've ever picked up a bottle and felt that something was off, your instinct was probably right. There are a handful of standard tricks the broader supplement industry uses, and once you can name them, you can spot them on every shelf. We refuse to ship a product that uses any of them.

Trick #1: The proprietary blend

A "proprietary blend" lets a brand list a total weight (say, "Longevity Matrix™ — 800mg") without telling you how much of each ingredient is actually inside. Often the marquee ingredient — the one on the front of the label — is a tiny fraction of the blend, and the rest is filler that happens to be cheap. The legal trick is real: the FDA only requires the total blend weight, not the breakdown. Our label rule is the opposite — every active ingredient is listed individually with its exact milligram dose, every time, with no exceptions and no blends.

How to spot it on competitor labels: any phrase ending in "blend," "matrix," "complex," or "formula" followed by a single combined milligram figure. If the front label says "Longevity Stack — 800mg" but the supplement facts panel doesn't break out NMN / resveratrol / pterostilbene / TMG individually, you have no way to know whether you're buying 600mg of NMN and 200mg of filler, or 50mg of NMN and 750mg of rice flour. The legal trick is that both versions can ship the same label.

Trick #2: The headline ingredient at fairy-dust dose

The bottle says "Ashwagandha." The supplement facts panel reveals 30mg per capsule. The peer-reviewed literature on ashwagandha (KSM-66, Shoden) uses 300–600mg of standardized extract per day (Chandrasekhar 2012 Indian J Psychol Med; Lopresti 2019 Medicine; Salve 2019 Cureus). Thirty milligrams isn't ashwagandha. It's window dressing — enough to legally print the word on the front, not enough to do anything in your body. We dose to clinical-trial ranges or we don't claim the ingredient. Our Ashwagandha KSM-66 600mg ships at the full dose used in the cortisol and sleep trials, not a fraction of it.

The catalog version of this rule: Berberine 500mg per capsule (matching Yin 2008 / Lan 2015 metabolic trials, dose to be split 2–3× daily for the full 1,000–1,500mg trial dose). NMN at 500mg and 1,000mg (paralleling Yamaguchi 2022 / Yoshino 2021 / Igarashi 2022 human trials). trans-Resveratrol 600mg (Timmers 2011 / Brasnyó 2011 metabolic dosing). Glutathione 500mg reduced GSH (Sinha 2018 / Richie 2015 oral GSH absorption work). Quercetin 500mg with bromelain potentiation. Curcumin 1,000mg + 5mg BioPerine (the 20× absorption combo per Shoba 1998 Planta Med). When the evidence is range-based, we err on the high-clinical end, not the cheaper one.

Trick #3: The cheap form of the right molecule

Magnesium oxide is the cheapest magnesium on earth and also the worst-absorbed — bioavailability under 4% in most studies versus 25–40% for chelated bisglycinate. It's still in roughly half the magnesium products on the market because it lets the brand print "400mg of magnesium" on the label cheaply. Our Magnesium Glycinate uses TRAACS bisglycinate at 400mg elemental, the form the sleep, NAD+ methylation, and recovery studies actually used (Abbasi 2012 J Res Med Sci; Yamadera 2007 Sleep Biol Rhythms; DiNicolantonio 2018 Open Heart). Same pattern with vitamin K (we ship MK-7 from natto, not MK-1 or MK-4 — Knapen 2015 longer half-life data), creatine (micronized for solubility), and curcumin (with BioPerine, because raw curcumin has near-zero absorption without it).

The form-matters checklist on a product page: trans-resveratrol (not cis), trans-pterostilbene, β-NMN (not the α-anomer), reduced GSH glutathione (not oxidized GSSG), liposomal Vitamin C (sunflower-lecithin phospholipid bilayer, not ascorbic acid alone), Type II UC-II collagen for the joint-cartilage actives, hydrolyzed marine peptides at 2–3 kDa molecular weight for the skin-collagen actives, low-molecular-weight (<50 kDa) sodium hyaluronate for transdermal hydration. Form is half the bioavailability story; dose is the other half. We publish both, every time.

Trick #4: The "kitchen sink" multi-ingredient capsule

If a product has fifteen ingredients in one capsule, simple math tells you no single ingredient is at a clinical dose — there's no room. Kitchen-sink formulas exist because they let a brand market across a dozen benefit categories at once, not because the molecules work better together. The senolytic, NAD+, and methyl-donor literature studied these molecules as standalone interventions. We sell them that way. If you want a stack, build it deliberately — don't inherit somebody else's blend at sub-therapeutic doses.

The deliberate exception: we ship two stacks where co-administration is the point — the NMN + Resveratrol Longevity Stack (sirtuin activation needs both substrate and modulator per Howitz 2003 Nature / Hubbard 2013 Science) and the NAD+ 5-in-1 Complete Mitochondrial Formula (multi-precursor entry product for buyers who want a stack-driven foundation in one bottle). Neither is a "kitchen sink" — both are specific co-administration designs anchored to published trial logic, with every active dosed individually and printed on the panel.

Trick #5: The "supports" wording shell game

"Supports cellular health." "Supports a healthy inflammatory response." "Supports cognitive function." Phrases like these are doing two jobs at once: they sound like they mean something, and they're vague enough to legally ship without evidence. We use specific mechanism language wherever the science supports it — "activates AMPK," "inhibits CD38," "raises NAD+ via the salvage pathway," "induces mitophagy via the PINK1/Parkin pathway," "selectively kills senescent cells via Bcl-2 family inhibition" — and we tell you when the evidence is preliminary instead of pretending it isn't.

The mechanism-disclosure rule on a product page: every active gets an explicit mechanism block (which pathway, which receptor or enzyme, which downstream effect), an explicit dose-rationale block (which trial, which dose, which population, which duration), and an explicit evidence-level flag (strong human trial / mechanistic + small human trial / mechanistic with preclinical only). When we ship something with preliminary evidence — for example, certain emerging epigenetic-clock interventions — we say so on the page, not in fine print three clicks deep.

Trick #6: The "natural" halo on a synthetic process

Almost every supplement on the market is manufactured in a lab. "Natural" on a longevity supplement label is usually marketing — what matters is the assay (how pure the molecule is), the form (whether your gut can absorb it), and the manufacturing standard (cGMP, ISO/IEC 17025-accredited third-party testing). We don't pretend our spermidine grew on a farm. It's wheat-germ-derived, standardized to 1% spermidine delivering 10mg per dose, third-party tested, and we publish the form and source on the product page.

What "natural" actually means in this catalog: the molecule's source organism (lanolin for D3, natto fermentation for K2 MK-7, Haematococcus pluvialis microalgae for astaxanthin, sunflower lecithin for liposomal carriers, fermented S. cerevisiae for reduced glutathione, beet molasses for TMG, Peruvian/Chilean wild-caught small pelagics for fish oil) is documented on the Ingredient Sourcing page. The lab process that turns that source organism into a CoA-traceable assay-verified raw is also documented. "Natural" is not the spec; mechanism + form + assay + heavy-metals + microbial + pesticide + traceability is the spec.

What we actually do

We formulate, source, and ship a focused catalog of longevity and rejuvenation supplements built around the pathways the science has converged on: the NAD+ pathway, mitochondrial biogenesis, cellular senescence, autophagy, sirtuin activation, methylation support, and the foundational nutrients (omega-3, magnesium, D3+K2, creatine, taurine) that everything else stacks on top of. The full framework is on our Our Science page — built around the 12 Hallmarks of Aging (López-Otín 2013 / 2023 Cell) and the canonical longevity targets in current literature.

You can read the long version of how we make sourcing and formulation decisions on our Our Science, Quality & Sourcing, and Ingredient Sourcing pages. The short version: we publish the dose, we publish the form, and we publish what the active ingredient is supposed to do mechanistically — not just what it "supports."

The catalog is intentionally narrow. We will probably never sell forty different multivitamins or chase whatever ingredient TikTok discovers this quarter. We add a SKU when we believe the evidence is strong enough — not when the trend is. That's why our shelves include things like Calcium Alpha-Ketoglutarate (Asadi Shahmirzadi 2020 Cell Metab), Urolithin A (Andreux 2019 Nat Metab), Spermidine (Eisenberg 2016 Nat Med), and Fisetin (Yousefzadeh 2018 EBioMedicine; Mayo AFFIRM NCT03675724/NCT04210986) — molecules with serious peer-reviewed backing — instead of the ten flavor-of-the-week ingredients you'll see being seasonally promoted elsewhere.

The catalog also excludes categories on principle. Prescription-only longevity actives (rapamycin, metformin, dasatinib, lithium at supraphysiologic dose) are not in this store and will not be — those are physician-prescribed pharmaceuticals, not supplements, and shipping them as supplements would be both illegal and unsafe. Single-supplier proprietary actives without independent verification (TA-65, certain telomerase activators) are not in this store either — when only one company can verify the molecule, the customer cannot independently audit the assay. Stem-cell activators with weak mechanistic evidence are not in this store. The catalog narrows the universe to what is shippable as a supplement, individually testable for identity / potency / heavy metals / microbials / pesticides / residual solvents, and backed by at least one peer-reviewed human trial.

Our five formulation rules

Five rules govern every product we ship. They're not soft principles. They're the literal checklist a product has to pass before it makes it onto a shelf.

1. Clinical-trial doses, not "fairy dust" doses.

If the human evidence on an ingredient uses 500mg twice daily, we deliver 500mg twice daily — we don't hide 50mg behind a proprietary blend and hope you don't notice. The number on our label is the number that did the work in the trial.

What this looks like in the catalog: Berberine 500mg per capsule (matching the Yin 2008 / Lan 2015 metabolic trials). Ashwagandha KSM-66 600mg (Lopresti 2019 / Salve 2019 cortisol and sleep work). NMN at 500mg and 1,000mg (paralleling the Yamaguchi 2022 / Yoshino 2021 / Igarashi 2022 human trials). Resveratrol 600mg trans-resveratrol (Timmers 2011 Cell Metab / Brasnyó 2011 metabolic dosing). Glutathione 500mg reduced GSH (Sinha 2018 / Richie 2015 oral GSH absorption work). Quercetin 500mg (the Mayo D+Q senolytic studies dose quercetin alongside dasatinib at high single-day doses; we ship the daily senolytic-stack-compatible dose). Fisetin 500mg (the Mayo AFFIRM trial pulse-dose framework). When the evidence is range-based, we err on the side of the higher clinical dose, not the cheaper one.

2. Bioavailable forms by default.

Magnesium glycinate instead of magnesium oxide. Liposomal direct-NAD+ where the absorption literature supports it. Curcumin with BioPerine. Vitamin K2 as MK-7. The cheap form is almost never the form the studies used.

What this looks like in the catalog: Magnesium TRAACS bisglycinate (chelated, ~4× the absorption of oxide). Curcumin 95% with BioPerine 5mg (BioPerine increases curcumin bioavailability roughly 20-fold per Shoba 1998). Vitamin K2 as MK-7 (3-day half-life vs. ~hours for MK-1; better arterial calcium routing per Sato / Knapen 2015 Br J Nutr). Micronized creatine monohydrate (smaller particles dissolve cleanly — non-micronized clumps and grits). NR berry stick packs (NR has the cleanest pharmacokinetic data of the NAD+ precursors per Trammell 2016 / Martens 2018 / ChromaDex). Liposomal direct NAD+ (sunflower lecithin phospholipid bilayer, ≥90% encapsulation efficiency). Liposomal Vitamin C (bypasses the SVCT1/2 transporter saturation that caps oral ascorbic acid). Form matters as much as dose. Sometimes more.

3. Single-actives where the evidence is single-active.

Most senolytics, NAD+ precursors, and methyl donors were studied as standalone interventions. We sell them that way too — so you can stack them deliberately instead of inheriting someone else's blend.

What this looks like in the catalog: Fisetin 500mg as a standalone (so you can run the Yousefzadeh / Mayo high-pulse senolytic protocol if that's what you're after). Quercetin 500mg as a standalone. NMN 500mg as a standalone and NMN 1,000mg as a standalone. TMG 1,000mg as a standalone (so people running NMN can methyl-buffer at their own dose). Apigenin 50mg as a standalone. NAC as a standalone + Glycine as a standalone (so GlyNAC stack runners can dose at the Sekhar 2021 trial ratio). The point: if you've already done the reading, we want to give you the building blocks, not pre-decide your stack for you.

4. Stacks where the evidence is stack-based.

NMN was studied alongside resveratrol. Vitamin D3 was studied alongside K2. Marine collagen has stronger skin endpoints when paired with vitamin C and hyaluronic acid. Where co-administration matters, we make a bundle and price it accordingly — not because bundling is good marketing, but because the molecules need each other to work.

What this looks like in the catalog: The NMN + Resveratrol Longevity Stack (sirtuin activation requires both substrate and modulator). D3 + K2 in one softgel (D3 raises serum calcium; K2 routes it to bone instead of arteries — taking D3 alone is a known issue per Geleijnse 2004 Rotterdam). Marine Collagen + Biotin + Hyaluronic Acid bundle (the human skin trials use this combination, not collagen in isolation; Proksch 2014 Skin Pharmacol Physiol + Oe 2017 Clin Cosmet Investig Dermatol). NAD+ 5-in-1 for buyers who want a stack-driven foundation in one bottle. Stacks are formulated against published co-administration data, not against marketing convenience.

5. No ingredient gets in without a mechanism.

If we can't answer "what does this molecule do, on which pathway, at what dose, in what timeframe?" — it doesn't ship. Trendy names without trial data are not in our catalog. We've turned down ingredient suggestions in our own product roadmap when the literature couldn't support the mechanism. We will keep doing that.

What this looks like in practice: The Hallmarks of Aging framework (López-Otín 2013 Cell, updated 2023 Cell) is the spine of the catalog. Every active maps to at least one hallmark — genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, dysbiosis, and disabled macroautophagy. If a proposed ingredient doesn't have a clean mechanistic case in at least one of those — and ideally a peer-reviewed human trial behind it — it doesn't get a SKU. The full per-Hallmark mapping is on our Our Science page, with H1–H12 deep-dives and per-Hallmark catalog cross-links.

How we source and manufacture

Sourcing is where most supplement quality is won or lost, and where almost no brand wants to talk publicly. Here's how we actually do it. The full per-ingredient sourcing detail — country of origin, isomer purity, branded raw spec, capsule shell type, pesticide/heavy-metal limits — is on the Ingredient Sourcing page; this section is the operating-rules summary.

Raw material qualification

Every active ingredient has to be sourced from a supplier that can produce a Certificate of Analysis (CoA) with assay percentage, identity confirmation (typically HPLC or UPLC), heavy metals testing (lead, mercury, arsenic, cadmium against Cal Prop 65 daily limits — Pb ≤0.5µg, Hg ≤0.3µg inorganic / 0.7µg methyl, Cd ≤4.1µg, inorganic As ≤10µg), microbial limits per USP <2021>/<2022> (total aerobic plate count, yeast/mold, E. coli, Salmonella), residual solvents per USP <467> where applicable, and EU-MRL pesticide screens for botanically-derived raws. If the CoA is missing, ambiguous, or copy-pasted from a generic template, the lot doesn't move forward — period.

Branded vs. generic raws

For ingredients where a branded form has run the bulk of the human trials, we use that branded form. KSM-66 ashwagandha (Ixoreal Biomed, root-only milk+water green-chemistry extraction, ≥5% withanolides) is the form most of the cortisol and sleep literature is built on, so that's what we ship. BioPerine (Sabinsa, ≥95% piperine) is the form 95% of the curcumin co-administration trials use. TRAACS bisglycinate (Albion/Balchem, FT-IR-verified true chelate) for magnesium. Where there's no meaningful branded-vs-generic difference in the literature, we use the lowest-cost compliant raw — and we tell you which it is.

Manufacturing standards

Finished products are manufactured in cGMP-compliant facilities (current Good Manufacturing Practice — the FDA's published quality standard for dietary supplements, 21 CFR 111). Encapsulation, blending, and bottling are run on equipment that has documented batch records, in-process weight checks, and finished-product release testing. Every finished lot has a unique batch number that traces back to its raw material lots, its manufacturing date, and its release-test results. Bottles ship induction-sealed and tamper-evident, in opaque containers with a desiccant where the active is moisture-sensitive (NMN especially). Capsule shell defaults to HPMC vegan plant cellulose, with gelatin/fish-gelatin softgels reserved for the lipid-soluble actives that need them (D3+K2, omega-3, astaxanthin).

Third-party verification

For our most-trafficked actives — NAD+ precursors, senolytics, the foundational stack — we run independent third-party assays in addition to the manufacturer's release data. The assay confirms identity and label-claim accuracy on a finished bottle, not just on the raw material. ISO/IEC 17025-accredited labs run the heavy-metals and microbial panels. If the third-party number doesn't match the label within tolerance, the lot doesn't ship to customers. The full process is on our Quality & Sourcing page.

Per-batch CoA available on request

Once a bottle is in your hands, the batch code on the bottom of the label traces back to a specific lot's CoA. To request the CoA for your lot, email support@truehealthprotocol.health with four fields — order number, product name, batch code, expiration date — and we'll send back the manufacturer's release CoA plus, where applicable, the third-party verification report. If something on the CoA looks off (a heavy-metals number above tolerance, an assay below 90% of label claim, a microbial result outside USP limits), we replace the bottle or refund without question. That's the operational meaning of the brand commitments below.

Country of origin transparency

We publish the country of origin for every active raw on the Ingredient Sourcing page. Most actives in this category are produced in a small handful of countries (the United States, India, Japan, China, Switzerland, Australia, Peru, Chile, and a few others depending on the molecule), and we'd rather tell you exactly where each ingredient comes from than hide behind "globally sourced." A representative slice:

Manufacturing partners and the supply chain you'll see on a product page

One of the most-asked customer questions is "who actually makes this?" The honest answer: True Health Protocol is the consumer-facing brand and the formulation-spec / quality-control / customer-experience layer; the physical manufacturing is handled by cGMP-compliant contract manufacturers and by named partner labs whose patent-grade actives appear on the product page where they're used.

That model is standard practice in the supplement industry — the manufacturers of finished bottles are typically not the same companies that ship them to customers. What's not standard is naming the partner labs and their patent-grade raws on the product page. We do that. Concretely:

• Selerb co-formulated SKUs. Our flagship multi-precursor NAD+ entry product, NAD+ 5-in-1 Complete Mitochondrial Formula, is built in partnership with Selerb. The supplier and partnership are listed on the product page rather than hidden under our own private label.
• Patent-grade raw partners named on the page. KSM-66 (Ixoreal Biomed) appears on the Ashwagandha page. BioPerine (Sabinsa) appears on the Curcumin page and the Apigenin page. TRAACS bisglycinate (Albion/Balchem) appears on the Magnesium Glycinate page. Creapure-spec micronized creatine appears on the Creatine page.
• Trial-grade raws referenced on the page. When a specific trial used a specific patent or branded form (Mayo AFFIRM fisetin batch spec, Andreux 2019 Mitopure-grade urolithin A, Asadi Shahmirzadi 2020 TruDiagnostic-validated CaAKG, Singh/Bhasin 2023 taurine pharm-grade), the trial spec is referenced on the page so the buyer knows whether the SKU mirrors the trial substrate.
• One product, one named partner, one bottle — not private-labeled across multiple brand identities on this site. Some industry players ship the same physical bottle under three different storefronts at three different prices and call them three different "brands." We don't do that. The All Products collection is the complete catalog; what's on this storefront under the True Health Protocol name is not on this storefront under any other brand name.

The legal entity, business address, registration disclosure, and contact-information block are on the Contact & Business Information page. The customer-experience contact is support@truehealthprotocol.health.

What we won't do

We won't make disease claims. We're a supplement company; we are not your doctor, and our products are not drugs. The FDA evaluates drugs, not dietary supplements, and we will never pretend otherwise on a label. Statements on this site have not been evaluated by the FDA. Our products are not intended to diagnose, treat, cure, or prevent any disease.

We won't run urgency timers, fake scarcity, or spin up "limited drops." Your cellular biology operates on a timescale of months and years, not 24-hour flash sales. If you see a discount on the site, it's because we ran the math, not because a script reset it overnight to look fresh.

We won't ship a product to you that we wouldn't take ourselves. If we wouldn't trust the assay, we don't ship the lot. If we wouldn't trust the supplier, we don't list the SKU. If a product can't pass our internal taste, capsule-quality, and disintegration test (USP <701>), it goes back to the manufacturer.

We won't pretend that supplements replace sleep, training, sunlight, protein, or relationships. They don't. They're a layer on top of those things — a real layer, but a layer. People who sleep five hours a night and eat from gas stations don't get rescued by NMN. We'll be the first to tell you that. Our recommended starting checklist on the Getting Started page actually covers the upstream variables (vitamin D >30 ng/mL, ferritin in range, thyroid screen, sleep apnea screen, protein floor, alcohol cap) before the senolytic and mitochondrial layers.

We won't stack ten ingredients into one capsule to expand the marketing surface. Single-active SKUs let you build a stack that fits your own bloodwork, age, training pattern, and goals. The world doesn't need another fifteen-ingredient "men's longevity matrix." It needs clean, dosed, traceable single actives.

We won't sell our customer email list. We won't run dark-pattern checkout flows that pre-check upsells without your consent. We won't run subscription products that are quietly impossible to cancel. The site says what it does and does what it says. Cancel any subscription one-click anywhere in the customer's account — no support call required.

We won't optimize the catalog around margin alone. Some of our highest-cost SKUs (urolithin A, calcium AKG, NR, reduced GSH glutathione) carry the lowest margins in the lineup because the raws are expensive and we hold the dose to the literature anyway. That's by design.

We won't pretend an Amazon-counterfeit-risk problem doesn't exist. Amazon's commingled-inventory rules let third-party sellers pool their stock with a brand's authentic stock under one product listing — meaning what shows up at your door bearing a "True Health Protocol" label has a non-zero probability of being something else. The only way to guarantee an authentic bottle is to buy from this storefront. Per Labdoor / CR 2022–23 testing, third-party certification on Amazon supplements is rare; commingled-inventory counterfeit risk is real; and CoAs on request are not part of the Amazon listing flow.

We won't rotate the brand identity to chase trends. The 12-Hallmark framework underneath the catalog is anchored to Cell-published peer review, not to whatever today's social platform is highlighting. The framework will get updated as the literature does (the 2023 update added dysbiosis and split chronic inflammation off as its own hallmark); the brand stance — clinical-trial doses, bioavailable forms, single-actives where evidence is single-active, named-partner manufacturing — will not.

Who this catalog is built for

True Health Protocol is built for people who already do their own research and just want a brand they don't have to second-guess. People who read the supplement facts panel before they read the front of the label. People who know what "trans-resveratrol" means and why micronized creatine matters. People who would rather take three single-ingredient capsules they understand than one fifteen-ingredient blend they can't decode.

Concretely, the catalog tends to fit four kinds of customers:

The longevity-curious researcher — usually 30s to 50s, has read Sinclair's Lifespan or Attia's Outlive, follows the Hallmarks of Aging conversation, wants to run an NAD+ stack with an honest dose. Most of our flagship NMN, NR, resveratrol, and TMG buyers fall here. The right entry point is the NAD+ Family collection plus the NMN + Resveratrol Longevity Stack.

The performance optimizer — already trains, already sleeps, already eats well, wants the foundational layer (creatine, omega-3, magnesium glycinate, vitamin D3+K2, taurine) plus targeted recovery and energy actives (CoQ10, ashwagandha, glutathione). Our creatine, omega-3, taurine, and ashwagandha SKUs are built for this person. The right entry point is the Foundational Health collection plus the Longevity Essentials bundle.

The skin/beauty stack builder — typically 35+, looking past collagen-only marketing toward the full protein-cofactor-antioxidant trio (collagen + vitamin C + hyaluronic acid + biotin) and the senolytic/inflammation layer underneath it. Our Beauty & Longevity Stack, Multi Collagen Complex, and HA + Vitamin C SKUs serve here. The right entry point is the Skin Protocol collection plus the Collagen collection.

The metabolic-health rebuilder — wants the AMPK / mitochondrial / glucose-handling layer (berberine, alpha-lipoic acid, CoQ10, magnesium, taurine), often after bloodwork raised a flag. Our berberine, alpha-lipoic acid, and CoQ10 SKUs anchor this segment. The right entry point is the Metabolic collection plus the Cardiovascular Longevity collection.

Two further customer segments — less common but well-served — round out the picture: the fertility-curious couple (CoQ10 + foundational + omega-3, paired with the Fertility collection), and the senolytic-protocol runner (Fisetin + Quercetin + Apigenin pulse-dosing per the Mayo AFFIRM framework, paired with the Senolytics collection).

If you're new to longevity supplementation, start with our Getting Started guide — it walks through the foundational stack first, before you go anywhere near the more advanced senolytic and mitochondrial protocols. If you already know what you're looking for, the Protocols page lays out the full stacks by goal: Cellular Longevity, Beauty & Skin, and Metabolic Health.

Catalog at a glance — by Hallmark, by goal, by onboarding tier

The 40-SKU catalog is organized along three independent axes — by Hallmark of Aging (the underlying mechanism), by customer goal (the outcome you came in for), and by onboarding tier (where in your journey you are). Same products, three different ways to find the right one.

Axis 1 — by Hallmark

• Genomic instability + sirtuin substrate (NAD+ pathway): NAD+ Family · NMN — covering NMN, NR, direct liposomal NAD+, NAD+ Daily Boost, NAD+ 5-in-1, NAD+ Pure Focus, and NR berry stick packs.
• Epigenetic alterations (methylation + sirtuin modulators): Calcium AKG, Spermidine, TMG, Glycine, Resveratrol, Pterostilbene.
• Cellular senescence (senolytics): Senolytics — Fisetin, Quercetin, Apigenin.
• Mitochondrial dysfunction (biogenesis + mitophagy): Mitochondrial Renewal — CoQ10, PQQ, Urolithin A, ALA.
• Loss of proteostasis + chronic inflammation (antioxidant defense): Antioxidants — Glutathione, NAC, Liposomal Vitamin C, Curcumin, Astaxanthin.
• Deregulated nutrient sensing (AMPK + insulin): Metabolic — Berberine, ALA.
• Foundational substrate (the always-on floor): Foundational Health — D3+K2, Magnesium Glycinate, Omega-3, Taurine, Creatine, Multi Collagen, Liposomal Vit C.
• Altered intercellular communication (HPA axis + cortisol): Ashwagandha KSM-66, Magnesium Glycinate.
• Beauty / connective tissue layer: Collagen · Skin Protocol · Beauty & Anti-Aging — Marine Collagen, Multi Collagen Powder, Biotin, HA + Vitamin C, Beauty & Longevity Stack.

Axis 2 — by goal

• "I want to raise NAD+ honestly": NAD+ Family · NMN — start with NMN 500mg or 1,000mg + TMG methyl-buffer + optional Resveratrol or Pterostilbene as the sirtuin modulator.
• "I want to clear senescent cells": Senolytics — Fisetin pulse-dose + optional Quercetin / Apigenin layer per the Mayo AFFIRM framework.
• "I want better mitochondria": Mitochondrial Renewal — CoQ10 baseline + Urolithin A for mitophagy + PQQ for biogenesis + ALA for cofactor recycling.
• "I want better metabolic / glucose / lipid markers": Metabolic · Cardiovascular Longevity — Berberine + ALA + Omega-3 + Taurine + foundational layer.
• "I want better skin / hair / connective tissue": Skin Protocol · Collagen · Beauty & Anti-Aging — Multi Collagen + Liposomal Vit C cofactor + HA + Biotin + Astaxanthin antioxidant layer.
• "I want the always-on foundation": Foundational Health · Longevity Essentials — Daily Seven (D3+K2, Mag Glycinate, Omega-3, Multi Collagen, Vit C, Taurine, Creatine).
• "I want a fertility-stack starting point": Fertility — CoQ10 + Omega-3 + Foundational layer + the Showell 2017 Cochrane-mirrored cofactor combo.
• "I want stress / sleep / cortisol / HPA support": Ashwagandha KSM-66 + Magnesium Glycinate + Glycine.
• "I want a brain / cognitive layer": Brain & Cognitive Longevity — Omega-3 + Creatine + Glutathione + Curcumin + foundational layer.

Axis 3 — by onboarding tier

• Tier 0 — never taken a longevity supplement: read Getting Started, then run the Starter Bundles for 8–12 weeks before adding anything advanced.
• Tier 1 — taking foundational nutrients but no NAD+ / senolytic / mitochondrial: add the Longevity Essentials bundle and one Hallmark-targeted entry product (NMN, Urolithin A, or Fisetin) at week 4.
• Tier 2 — already running a basic NAD+ + foundational stack: layer in a sirtuin modulator (Resveratrol or Pterostilbene), a methyl donor (TMG), and a senescent-cell clearance pulse (Fisetin) per the Protocols guide.
• Tier 3 — comprehensive Hallmarks-anchored stack: all of the above plus the mitochondrial layer (CoQ10 + Urolithin A + PQQ + ALA), the antioxidant layer (Glutathione + NAC + Liposomal Vit C + Curcumin + Astaxanthin), and the skin / connective layer (Multi Collagen + HA + Biotin + Beauty Stack).
• Browse the entire shelf: All Products · Most Popular.

Three reading paths through the brand

Whichever entry point fits, here are the three reading paths the brand is built around.

Path 1 — newcomer: Getting Started → Starter Bundles → Longevity Essentials → Foundational Health → How It Works (month-by-month timeline). Treat the foundational layer as 8–12 weeks of training before the senolytic / mitochondrial / NAD+ layers.

Path 2 — goal-stack: Protocols → pick one of (Cellular Longevity / Beauty & Skin / Metabolic Health) → cross-link into the matching goal collections (NAD+ Family, Skin Protocol, Metabolic). Don't try to run all three goal stacks at once.

Path 3 — molecule-deep-dive: Our Science (12 Hallmarks framework) → Ingredient Sourcing (per-active spec, country of origin, isomer purity) → Quality & Sourcing → FAQ (drug interactions, dosing, timing, vegan, third-party testing). This is the right path if you came here already knowing why MK-7 beats MK-1 and you just want to verify the spec on the page matches the spec you came for.

The 30-day guarantee, in plain English

We back every product with a 30-day return window — opened or unopened, no restocking fee, no quiz to pass. If something doesn't work for you or doesn't sit right, email us and we'll refund it. The full terms are on our Refund Policy (formal language) and our 30-Day Guarantee page (operational language with edge cases for international, BNPL, gift orders, subscription, allergic reactions, and chargebacks). Bottom line: the burden of proof is on us, not on you.

Why 30 days specifically: most supplement effects in this category — sleep quality from magnesium glycinate, energy from CoQ10, training capacity from creatine, glucose handling from berberine — show up in the two-to-four-week window if they're going to show up at all. Thirty days gives you a real chance to evaluate. We'd rather you try a product, decide it isn't for you, and refund it than have you sit on a half-used bottle and quietly never come back.

The longer-arc effects — senolytic clearance pulses, mitophagy build-up, methylation-clock movement, GlyNAC glutathione restoration, foundational nutrient repletion — operate on 8–24 weeks. The 30-day guarantee is intentionally not the same as "you'll feel everything in 30 days." It is "if 30 days in you can already tell this product is wrong for you, you don't pay for it." For the longer-arc effects, what we ask in return is that you give the protocol the literature-anchored timeframe it actually needs, and we cover the safety floor on the early-evaluation window.

How we treat support

Customer support is run by humans who can read the same studies we do. We aren't running a chat widget that returns three boilerplate macros and a "ticket has been resolved" auto-close. If you ask us about dose, timing, stacking, methylation buffering, NAD+ pathway choice, or whether your supplement is interacting with a medication, we'll answer the actual question — or tell you when the question is one for your physician, not for us.

The kinds of questions we answer in the inbox every week:

• "I'm running NMN at 1g — do I need TMG, and at what dose?" (Yes; 500–1,000mg TMG split with the NMN dose buffers SAM-e depletion per the methylation-cycle literature.)
• "I take warfarin — can I add omega-3 + K2?" (We will not advise around an anticoagulant; that is your physician's call. We can show you the K2 / omega-3 / curcumin / ginkgo interaction class and let you take it to clinic.)
• "Should I take fisetin every day or pulse it?" (Pulse-dose, mirroring the Mayo AFFIRM framework — we'll lay out the literature-anchored pulse interval.)
• "My CoQ10 batch code is XYZ; can I see the CoA?" (Yes; we'll send the manufacturer's release CoA plus the third-party verification report within one business day.)
• "Is this product vegan / gluten-free / soy-free / non-GMO?" (We answer per-SKU and reference the Ingredient Sourcing page allergen-flag block.)
• "I had a reaction to a bottle — what do I do?" (Stop the product, email us, we refund without question and add the active to your account's allergy-flag list so future bundles route around it.)

Reach us at support@truehealthprotocol.health or via WhatsApp at +972 55 911 6990. We reply within one business day, usually faster. The full contact and business information is on our Contact & Business Information page, and the long-form Contact page covers the full set of inbound channels.

A note from the founder

I'm Katy Davidovich, the founder of True Health Protocol. I started this brand because I wanted to buy these products from somebody else and couldn't. The longevity space has gotten enormous in the last five years; the catalog of well-formulated, properly-dosed, transparently-sourced products has not grown nearly as fast. So I built one.

I'd rather move slowly and ship a small number of formulas I'm willing to put my name on than ship a sprawling catalog. I'd rather lose a sale because somebody decided our berberine is more expensive than the cheapest version on the market than ship a 200mg berberine and pretend it's a 500mg dose. I'd rather have you email me a hard question about dose stacking and not buy anything than have you buy something that doesn't fit your goals.

The team is small on purpose — formulation, sourcing, customer experience, content. There is no investor breathing down our necks pushing for hyper-growth shortcuts. That structure lets us say no to ingredients we can't defend, lets us hold dose to the literature, lets us name our manufacturing partners openly, and lets us run a real 30-day money-back guarantee without flinching. It also means I read the support inbox personally most days. If you write in, the reply at the other end is real.

That's the brand. If it lines up with how you think about your own health, welcome — and write to us with anything you want to dig into. support@truehealthprotocol.health.

Brand commitments — the operational checklist

The list below is not marketing copy. It's the set of operational commitments the team is held to. If we ever miss one of these, we want to hear about it — at support@truehealthprotocol.health.

• Every active dose is published on the product page. No proprietary blends, no hidden weights.
• Every active form is published on the product page. Bisglycinate, MK-7, trans-resveratrol, β-NMN, micronized creatine, reduced GSH, liposomal — the form is part of the spec.
• Every batch is cGMP-manufactured (21 CFR 111) and traceable by lot to its release-test results.
• Three-tier verification on every active: HPLC identity + ≥90% potency, ICP-MS heavy metals against Cal Prop 65 limits, USP <2021>/<2022> microbial + USP <467> residual solvent + EU MRL pesticide where applicable.
• Third-party assay verification on the most-trafficked actives. We don't take the manufacturer's word for it. ISO/IEC 17025-accredited labs.
• Country of origin transparency for every active raw, published on our sourcing page.
• Per-batch CoA available on request via support@truehealthprotocol.health, with the four-field request format (order # + product + batch code + expiration).
• Plain-language mechanisms on every product page. What it does, on what pathway, at what dose, in what timeframe.
• Honest "evidence level" framing when we describe an ingredient — strong human trials vs. preclinical evidence vs. emerging.
• Clear stack guidance when we ship a single active that is normally co-administered (NMN buyers get TMG-pairing guidance; D3 buyers get K2-pairing guidance; collagen buyers get vitamin C cofactor guidance).
• 30-day, no-questions, opened-or-unopened return policy, executed by a human, not a bot. Original shipping refunded too.
• No dark-pattern checkout. No auto-checked upsells, no trick subscription enrollments, no pre-applied add-ons.
• One-click subscription cancellation for any subscription product, anywhere in the customer's account, no support call required.
• No selling, renting, or sharing your email list. Ever, for any reason.
• No misleading scarcity timers or inflated "compare-at" pricing. The discounts on the site are the actual discounts.
• No paid sponsorship reviews dressed up as independent endorsements on our own pages.
• No private-labeling the same product under multiple brand identities on this site.
• Manufacturing partners named on the page where they're used — Selerb, Ixoreal Biomed, Sabinsa, Albion/Balchem, Creapure-spec.
• Every product page links to its primary peer-reviewed references on Our Science.

How this brand got here — a short timeline

Brand timelines tend to be glossy. This one is operational. The intent is to give you a sense of how the catalog and the standards moved.

• Origin (the personal-problem phase). Years of supplement-aisle frustration; reading Lopez-Otín 2013 Cell on the Hallmarks of Aging and realizing the framework already mapped to the entire longevity-supplement category. Decision: build a brand that makes the framework explicit, and ship every active at trial dose in trial form.
• Catalog v1 — the foundational layer. The Daily Seven (D3+K2, Magnesium Glycinate, Omega-3, Multi Collagen, Vitamin C, Taurine, Creatine) plus the secondary foundations (GlyNAC = NAC + Glycine, ALA, Curcumin, Ashwagandha KSM-66, TMG). Trial-anchored doses, branded raws where the trials used branded raws, single-actives where the evidence is single-active.
• Catalog v2 — the NAD+ pathway buildout. NMN at 500mg + 1,000mg, NR berry stick packs, Liposomal direct NAD+, NAD+ Daily Boost, NAD+ Pure Focus, the multi-precursor NAD+ 5-in-1 entry product (with Selerb partnership disclosed on the product page), TMG methyl-buffer, Resveratrol 600mg + Pterostilbene 100mg sirtuin modulators.
• Catalog v3 — the senolytic + mitochondrial layer. Fisetin 500mg (Mayo AFFIRM trial dose-mirror), Quercetin 500mg, Apigenin 50mg + BioPerine. Mitochondrial: CoQ10 400mg, Urolithin A 500mg (Mitopure-grade postbiotic, not ellagic-acid precursor), PQQ 20mg, ALA 600mg.
• Catalog v4 — the epigenetic + beauty layer. Calcium AKG 1,000mg (TruDiagnostic-validated form), Spermidine 10mg (1% wheat germ extract). Beauty: Marine Collagen 5,000mg, Multi Collagen Complex (Types I/II/III/V/X), Multi Collagen Powder, Biotin 10,000mcg, HA 200mg + Vitamin C, Astaxanthin 12mg, Beauty & Longevity Stack.
• Page architecture buildout. The customer-journey pages all built to flagship spec — Our Science (12 Hallmarks framework), Ingredient Sourcing, Quality & Sourcing, Getting Started, How It Works, Protocols, FAQ, Guarantee.
• Collection architecture. 13 smart collections (NAD+ Family, NMN, Senolytics, Mitochondrial Renewal, Cardiovascular Longevity, Brain & Cognitive Longevity, Antioxidants, Collagen, Metabolic, Foundational Health, Fertility, Most Popular, All Products) + 5 custom collections (Starter Bundles, Longevity Essentials, Beauty & Anti-Aging, Skin Protocol, Top Picks).
• Where the brand is now. Founder-led, privately held, no outside capital. 40 active SKUs. Per-batch CoA on request. ISO/IEC 17025-accredited third-party verification on the most-trafficked actives. International shipping with US fulfillment partners. Customer support at one-business-day response. The catalog grows when the literature gives us a reason to add a SKU, not when the trend does.

Where to start

If you want our recommended path through the catalog, it's three steps:

1. Read Getting Started — it tells you which two or three foundational products to begin with before you build any further, and it covers the upstream variables (vitamin D status, ferritin, thyroid screen, sleep apnea screen, protein floor, alcohol cap) that often matter more than the supplement layer.

2. Pick one stack from the Protocols page — Cellular Longevity, Beauty & Skin, or Metabolic Health — based on what you actually care about right now. Don't try to run all three at once. Starting with one and giving it 8–12 weeks beats starting with three and abandoning all of them at week 4.

3. Give it eight to twelve weeks. Cellular biology is slow. The people who get the most out of supplementation are the ones who treat it like training, not like coffee. The week-by-week onboarding timeline is on How It Works; the senolytic / mitochondrial / methylation effects measured in trials operate on month-3-through-month-12 timeframes, not week-1.

If at any point you have questions about dose, timing, stacking, or interactions — write to us. We'd rather answer your question than have you guess. support@truehealthprotocol.health.

FAQ — about the brand

Are your products manufactured in the United States?

Finished products are manufactured in cGMP-compliant facilities (United States and partner facilities, depending on the SKU). Raw materials are sourced from the country with the strongest production for that specific molecule — see Ingredient Sourcing for the per-active country-of-origin breakdown. cGMP itself is the FDA's published quality standard for dietary supplements (21 CFR Part 111) and applies to the finished-bottle manufacturing step regardless of where the raw was grown or extracted.

Are your products third-party tested?

Every finished lot has manufacturer release testing (identity, potency, microbial, heavy metals). For our most-trafficked actives — NAD+ precursors, senolytics, and the foundational stack — we run additional independent third-party assays on finished bottles via ISO/IEC 17025-accredited labs. Details on the Quality & Sourcing page; the per-active testing-protocol table is on the Ingredient Sourcing page (HPLC identity, ICP-MS heavy metals, USP <2021>/<2022> microbial, USP <467> residual solvent, USP <701> disintegration).

Do you have a Certificate of Analysis (CoA) available?

Yes — by request, per lot. Email support@truehealthprotocol.health with four fields: your order number, the product name, the batch code on the bottom of the label, and the expiration date. We send the manufacturer's release CoA, and where applicable, the third-party verification report. Turnaround is typically one business day.

Are your products NSF, USP, or Informed Sport certified?

Not all products in the catalog. Where a SKU carries an additional third-party certification (NSF Contents Certified, Informed Sport, etc.), it's noted on the product page. We will be expanding which SKUs carry those marks over time. If a specific certification matters to your use case (for example, drug-tested athletes who need Informed Sport), email us before ordering and we'll tell you which SKUs are eligible right now.

Is "True Health Protocol" the same brand as Selerb or any other label?

True Health Protocol is the consumer-facing brand. A few SKUs in the catalog use co-formulated products from partner labs (for example, our flagship NAD+ 5-in-1 product is built in partnership with Selerb). The supplier and partnership are listed on the product page where applicable, and we don't private-label the same product under multiple brand identities on this site. The All Products collection is the complete catalog.

Do you offer wholesale, practitioner, or affiliate programs?

Yes. Email support@truehealthprotocol.health with your background — clinic specialty / practice type / monthly volume estimate, or audience size and platform for affiliate. We'll respond within one business day with terms.

Are you a public-benefit corporation, certified B Corp, or registered charity?

Currently no — we're a small, founder-led, privately-held supplement company with international and US fulfillment partners. The legal entity, address, and registration disclosure are on the Contact & Business Information page. Operational transparency is something we've chosen to do publicly even without a certification badge.

Do you ship internationally?

Yes. We ship to the United States and most international destinations. Customs, duties, transit times, carrier breakdown, and per-zone delivery estimates are covered in detail on the Shipping Policy page. The shipping-zone summary is also in the FAQ's shipping section.

Where are reviews — why isn't there a 4.9-star widget on every page?

We don't paste paid or solicited reviews onto product pages. Where reviews exist, they're real, post-purchase, and unfiltered. We'd rather ship one product page with eight honest reviews than another with eight hundred fake ones. If you've taken one of our products and want to share what it did or didn't do, write to us — that feedback shapes the catalog.

What do you do when a product doesn't work for me?

Refund it. The 30-day window is opened-or-unopened, no restocking fee, no quiz, no friction. Email support, include your order number, and we'll handle it from there. Original shipping refunded too. Full terms on the Refund Policy; the philosophy and the edge cases (international, BNPL, gift orders, subscriptions, allergic reactions, chargebacks) are on the 30-Day Guarantee page.

Can you tell me what to take?

We can tell you what the literature supports, what dose the trials used, and which ingredients pair with which. We can't tell you what to take in the way your physician can — meaning we won't diagnose anything, won't replace your doctor, and won't recommend stopping a prescribed medication. For specific medical questions — pregnancy, lactation, drug interactions, pre-existing conditions — talk to your physician first. For "what's a sensible 90-day starter stack for somebody in their forties who lifts and sleeps okay" — yes, that we can answer.

Do you carry rapamycin, metformin, dasatinib, or other prescription longevity actives?

No, and we will not. Those are physician-prescribed pharmaceuticals, not dietary supplements; selling them as supplements would be both illegal and unsafe. If a clinician has prescribed one of those for you, your supplement stack has to be coordinated with them — not bought from us as a substitute.

Do you carry stem-cell activators, telomerase activators, or NAD+ "boosters" without trial data?

No. The catalog is filtered to actives with at least one peer-reviewed human trial and a clean mechanistic case in at least one Hallmark of Aging. Single-supplier proprietary actives (TA-65, certain telomerase activators) and stem-cell activators with weak mechanistic evidence don't meet that bar. The Our Science page explains the inclusion criteria in detail.

I've never taken a longevity supplement — where do I start?

Read Getting Started, then run the foundational layer (the Daily Seven — D3+K2, Mag Glycinate, Omega-3, Multi Collagen, Vitamin C, Taurine, Creatine) for 8–12 weeks before adding NAD+, senolytic, or mitochondrial actives. The Starter Bundles collection is the simplest entry point.

I'm trying to conceive — is your fertility stack safe?

The CoQ10 + Omega-3 + foundational layer in the Fertility collection mirrors the Showell 2017 Cochrane-aligned cofactor combo. However: several other catalog actives (ashwagandha, berberine, NMN at high dose, senolytics) are routinely paused during conception attempts and pregnancy under standard ACOG guidance. The FAQ's safety section covers the per-SKU pregnancy/lactation pause list, and we will always defer to your obstetrician's specific guidance over ours.

I take a prescription medication — should I be worried about interactions?

The most-flagged interaction classes in this catalog are anticoagulants (warfarin: K2 + omega-3 + curcumin), statins (CoQ10 depletion), diabetes medications (berberine + ALA hypoglycemia risk), SSRIs/MAOIs (ashwagandha additive), chemotherapy or immunosuppressants (pause antioxidants and senolytics), and bisphosphonates (mag/calcium absorption). The FAQ's drug-interactions section covers each class in detail. The honest answer to "should I be worried" is "talk to your prescribing physician with the supplement list in hand" — we'll happily provide the interaction summary, but the prescribing decision is theirs.

Why is your berberine more expensive than the cheap one on Amazon?

Three reasons. First, the assay is verified — the actives in commingled-inventory listings on Amazon often aren't, per Labdoor / CR 2022–23. Second, the dose is held at the trial dose (500mg per cap, dosed 2–3× daily for 1,000–1,500mg/day, matching Yin 2008 / Lan 2015). Third, per-batch CoA is available on request. The cheap version isn't always wrong — but it isn't always right either, and you can't independently audit which case you're in. The CoA-on-request flow is what closes that gap.

What's actually different about this brand?

Three things. (1) The catalog is filtered to actives with peer-reviewed human-trial backing and clean Hallmark mechanism — no kitchen-sink blends, no fairy-dust doses, no "supports cellular health" wording. (2) The form on the panel matches the form the trials used — bisglycinate not oxide, MK-7 not MK-1, β-NMN not α-NMN, trans-resveratrol not cis, micronized creatine, liposomal where the absorption literature supports it. (3) The supply chain is named — partner labs (Selerb), patent-grade raws (KSM-66, BioPerine, TRAACS, Creapure-spec), country of origin per active, per-batch CoA on request. The Quality & Sourcing and Ingredient Sourcing pages are the operational version of that answer.

Reading list — go deeper

If you want to sit with the framework before you sit with the catalog, here are the most useful in-house pages and the order to read them.

• Our Science — 12 Hallmarks of Aging and the catalog that maps to them — the conceptual spine.
• Getting Started — where to begin — the practical entry point for a Tier 0 newcomer.
• How It Works — from first order to month 6 — the week-by-week timeline of what changes when.
• Protocols — supplement stacks by goal — Cellular Longevity / Beauty & Skin / Metabolic Health stacks with full doses.
• Foundational Health — the Daily Seven longevity essentials — the always-on floor under everything else.
• Ingredient Sourcing — origins, purity specs, CoA on request — the per-active country-of-origin and isomer-purity breakdown.
• Quality & Sourcing — manufacturing, testing, traceability — the cGMP / ISO/IEC 17025 / per-batch CoA process.
• FAQ — frequently asked questions — dosing, drug interactions, pregnancy, vegan, third-party testing, shipping, returns.
• 30-Day Keep-the-Bottle Guarantee — operational policy with edge cases for international, BNPL, gift orders, subscriptions, allergic reactions, chargebacks.
• Contact · Contact & Business Information — full set of inbound channels and the legal-entity disclosure.
• Refund Policy · Shipping Policy · Terms of Service · Privacy Policy — the formal-language policy mirrors of the operational pages.

Selected primary references

The trial / framework references behind the formulation rules, the Hallmarks framework, and the catalog organization. Full per-active references are on each product page and in the per-Hallmark deep-dives on Our Science.

• López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The Hallmarks of Aging. Cell. 2013;153(6):1194–1217.
• López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding universe. Cell. 2023;186(2):243–278.
• Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224–1229.
• Yamaguchi S, Irie J, Mitsuishi M, et al. Safety and efficacy of long-term (12-week) NMN administration. Nutrients. 2022.
• Igarashi M, Nakagawa-Nagahama Y, Miura M, et al. Chronic NMN supplementation in older men. npj Aging. 2022.
• Trammell SAJ, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016;7:12948.
• Martens CR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018;9(1):1286.
• Brakedal B, et al. The NADPARK study: a randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease. Cell Metab. 2022;34(3):396–407.
• Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003;425(6954):191–196.
• Hubbard BP, Sinclair DA. Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci. 2014.
• Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18–28.
• Andreux PA, Blanco-Bose W, Ryu D, et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nat Metab. 2019;1(6):595–603.
• Asadi Shahmirzadi A, et al. Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice. Cell Metab. 2020;32(3):447–456.
• Eisenberg T, Abdellatif M, Schroeder S, et al. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016;22(12):1428–1438.
• Sekhar RV, et al. Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition. Antioxidants. 2021.
• Kumar P, Liu C, Hsu JW, et al. GlyNAC (glycine and N-acetylcysteine) supplementation in older adults reverses key aging hallmarks. Nutrients. 2022.
• Mortensen SA, Rosenfeldt F, Kumar A, et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO. JACC Heart Fail. 2014;2(6):641–649.
• Ziegler D, Low PA, Litchy WJ, et al. Efficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. Diabetes Care. 2011.
• Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69–81.
• Knapen MHJ, Braam LAJLM, Drummen NE, et al. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women: a double-blind randomised clinical trial. Br J Nutr. 2015.
• Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety. Indian J Psychol Med. 2012;34(3):255–262.
• Shoba G, Joy D, Joseph T, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64(4):353–356.
• Singh P, Gollapalli K, Mangiola S, et al. Taurine deficiency as a driver of aging. Science. 2023;380(6649):eabn9257.
• Forbes SC, Candow DG, Krentz JR, et al. Effects of creatine supplementation on properties of muscle, bone, and brain function in older adults: a narrative review. Nutrients. 2022;14(15):3104.
• Manson JE, Cook NR, Lee IM, et al. Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med. 2019;380(1):33–44 (VITAL).
• Bhatt DL, Steg PG, Miller M, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med. 2019;380(1):11–22 (REDUCE-IT).
• Pullar JM, Carr AC, Vissers MCM. The roles of vitamin C in skin health. Nutrients. 2017;9(8):866.
• Proksch E, Segger D, Degwert J, et al. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology. Skin Pharmacol Physiol. 2014;27(1):47–55.
• Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712–717.
• Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):R115.
• Belsky DW, Caspi A, Corcoran DL, et al. DunedinPACE, a DNA methylation biomarker of the pace of aging. eLife. 2022;11:e73420.
• Showell MG, Mackenzie-Proctor R, Jordan V, et al. Antioxidants for female subfertility. Cochrane Database Syst Rev. 2017.
• Camacho-Pereira J, et al. CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism. Cell Metab. 2016;23(6):1127–1139.
• Abbasi B, Kimiagar M, Sadeghniiat K, et al. The effect of magnesium supplementation on primary insomnia in elderly: a double-blind placebo-controlled clinical trial. J Res Med Sci. 2012.
• Yamadera W, Inagawa K, Chiba S, et al. Glycine ingestion improves subjective sleep quality. Sleep Biol Rhythms. 2007;5(2):126–131.

How we revise this page

This page is a living document, not marketing copy that ships once and freezes. The brand-stance commitments above are stable; the catalog and the supporting framework get updated as the literature does. Recent revisions:

• 2026-05 update: Expanded the sourcing section with the per-active country-of-origin table mirroring Ingredient Sourcing; added the Manufacturing partners section with named-partner disclosure (Selerb, Ixoreal Biomed, Sabinsa, Albion/Balchem, Creapure-spec); added the Catalog at a glance three-axis block; added the brand timeline; expanded the FAQ from 11 to 18 entries; added the selected primary references list and the reading list.
• Prior updates: Hallmarks framework refresh anchored to the 2023 update (dysbiosis added; chronic inflammation split off as its own hallmark); catalog re-organization to the 18-collection / 40-SKU shape; flagship rewrites of Our Science, Ingredient Sourcing, Getting Started, How It Works, Foundational Health, FAQ, and Guarantee.

Browse the catalog

The complete shelf, organized by the same three axes as above. Pick the entry point that fits — by Hallmark, by goal, or by onboarding tier.

• Smart collections (mechanism-anchored): Foundational Health · NAD+ Family · NMN · Senolytics · Mitochondrial Renewal · Cardiovascular Longevity · Brain & Cognitive Longevity · Antioxidants · Collagen · Metabolic · Fertility · Most Popular · All Products
• Custom collections (curated bundles): Starter Bundles · Longevity Essentials · Beauty & Anti-Aging · Skin Protocol · Top Picks
• Reading-first onboarding: Getting Started → How It Works → Protocols → Our Science

True Health Protocol. Formulated for people who do their research.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Information on this page is educational and is not medical advice. If you are pregnant, nursing, taking medications, or have a medical condition, consult your physician before starting any supplement. Individual results vary; the timeframes referenced reflect outcomes measured in the cited peer-reviewed trials and are not guarantees of personal effect.