FAQ — Frequently Asked Questions

Quick, science-anchored answers to the questions every customer asks before, during, and after a True Health Protocol order — products, stacks, dosing, drug interactions, pregnancy, vegan status, third-party testing, US shipping, returns, and what to actually expect week by week. Can't find your answer? Contact us at support@truehealthprotocol.health — we respond within one business day.

The 60-second answer

• What we sell: 40 clinical-dose longevity, NAD+, collagen, senolytic, metabolic, antioxidant, and foundational supplements built around the López-Otín 2013/2023 Hallmarks of Aging framework — see our science for the upstream mechanism map.
• Where we ship from: US fulfillment warehouse to all 50 states, typically 5–10 business days standard / 2–4 days expedited; international available with 8–18 day transit.
• How we're different: full mg-doses on the label (no proprietary blends), bioavailable forms (magnesium glycinate not oxide, MK-7 not MK-4, multi-type collagen not bovine-only), third-party COAs on every batch (quality & sourcing), and per-product trial-anchored dosing (where each active comes from).
• Where to start: use the Getting Started 8-row decision matrix to pick your goal, then read How It Works for the week-by-week protocol.
• Guarantee: 30-day money-back from delivery — see Our 30-Day Guarantee and Refund Policy.
• Safety floor: not a drug; if you take Rx (warfarin, statins, diabetes meds, SSRIs, immunosuppressants, chemo) or are pregnant/nursing, talk to your clinician before stacking — see the Drug Interactions section below.

Getting started

I'm new to longevity supplements. Where do I start?

Pick one primary goal: cellular energy & longevity, beauty (skin/hair/nails), or metabolic. Match it to a starter bundle — the NMN+Resveratrol Longevity Stack for energy, the Beauty & Longevity Stack for skin/hair/nails, or Berberine 500mg + ALA 600mg for metabolic. Run the foundation for 4 weeks before layering anything else. The full on-ramp is in Getting Started.

Should I start with a bundle or buy each product individually?

If you're new, start with a bundle — bundles ship the trial-validated ratios together and remove the "what dose pairs with what" friction. Once you know what's working at week 4–6, you can layer single SKUs on top. See Starter Bundles for the four pre-built starting points, or browse all 40 products if you already know what you want.

I'm 25 — is it too early to start? I'm 65 — is it too late?

Neither. NAD+ declines start in the 20s and accelerate after 40 (Yoshino 2021 Science: NAD+ in human muscle drops ~50% by age 50). The biggest evidence is for adults 40–80, but trials in 25-year-olds and 80-year-olds both show measurable benefit — the protocol just emphasizes different layers. After 60, prioritize foundation first (D3+K2, magnesium, omega-3, collagen, creatine) before adding senolytics or NAD+.

Do I need to be on a special diet for these to work?

No, but two non-negotiables make every supplement work better: hit your protein floor (1.6–2.2 g/kg body weight per day for the over-40 cohort, anchored to Bauer 2013 JAMDA PROT-AGE) and prioritize sleep. Time-restricted eating (12–14h overnight fast) potentiates AMPK-pathway products (berberine, ALA, NMN) but is optional. See Longevity Supplements After 40 for the full lifestyle pairing.

Where do I read more before ordering?

Three pages before your first order: Our Science (mechanism map), Protocols (six pre-built stacks by goal), and Getting Started (your day-1 protocol). After that, the Protocol Library blog has 20 deep-dive articles.

Products & stacks

What's the difference between NMN, NR, and direct NAD+?

All three raise NAD+ but enter the salvage pathway at different points. NMN (Pure NMN 500mg, NMN 1000mg Double Strength) is the most-studied human-trial precursor (Yoshino 2021, Yamaguchi 2022 Nutrients, Igarashi 2022 npj Aging). NR (Nicotinamide Riboside Hard Capsules, Liquid NAD+ NR Berry) is patented, well-tolerated, and has its own trial base (Martens 2018 Nat Commun, Conze 2019). Direct NAD+ (NAD+ Daily Boost, Liposomal NAD+ Ultimate 1000mg) skips the precursor step entirely. Most people start with NMN; the full breakdown is in NMN vs NAD+ and NMN vs NR. See the full NAD+ Family collection for all 7 SKUs.

What's the difference between Multi Collagen Complex (capsules) and Multi Collagen Peptides (powder)?

Same 5-type collagen profile (I, II, III, V, X), different format. Capsules are convenient and travel-friendly at 240 caps/jar (~30-day supply at 8 caps). Powder is unflavored and mixes into coffee or smoothies at 10–15g/day — the dose used in Proksch 2014 Skin Pharmacol Physiol and Shaw 2017 Am J Clin Nutr. For pure marine sourcing, see Marine Collagen Peptides 5000mg; full collection at Collagen Supplements.

What stacks do you recommend?

Six trial-validated pairings underneath every protocol:

• Sinclair stack — NMN + Resveratrol + TMG (NAD+/SIRT1 with methylation buffer) — Howitz 2003 Nature, Hubbard 2013 Science.
• Senolytic burst — Fisetin + Quercetin 2 days/month (zombie-cell clearance) — Yousefzadeh 2018 EBioMedicine.
• Mitochondrial renewal — Urolithin A + CoQ10 + PQQ (mitophagy + biogenesis) — Andreux 2019 Nat Metab.
• Glutathione master-antioxidant — Glycine + NAC + Glutathione (the GlyNAC stack) — Sekhar 2021, Kumar 2022 Nutrients.
• Metabolic AMPK — Berberine + ALA (glucose + lipid control) — Yin 2008 Metabolism, Ziegler 2011 NATHAN 1.
• Skin synthesis — Multi Collagen + Liposomal Vitamin C (P4H/LH cofactor) — Pullar 2017, Shaw 2017.

The full pairing logic — when to start each, what to layer at week 4 vs month 3 — is on How It Works and Protocols.

Can I take all of these together, or should I stagger?

You can take 5–7 capsules together with a single morning meal — there's no pharmacokinetic reason to stagger most longevity supplements. The exceptions: magnesium glycinate goes evening (sleep effect), glycine 1500mg goes 30–60 min pre-sleep (slow-wave sleep), berberine splits to your two largest meals (postprandial glucose), apigenin goes evening (CD38 timing), creatine can go any time but ideally post-workout if you train, and collagen+Vit C ideally goes pre-workout if you have joint goals (Shaw 2017 collagen-loading window). Senolytics (Fisetin, Quercetin) are pulsed 2 consecutive days/month, not daily.

Will this work without lifestyle changes?

You'll get some benefit (NAD+ rises, collagen synthesis increases, AMPK activates) — but the trial endpoints assumed reasonable nutrition, sleep, and movement. The five-leverage stack underneath every supplement: (1) protein floor 1.6–2.2 g/kg, (2) 7–9 hr sleep, (3) resistance training 2–3×/week, (4) 8,000+ steps/day, (5) alcohol cap (≤4 drinks/week). If you're missing two of these, fix them first — the supplement layer is multiplicative on top, not a substitute.

Which single product should I take if I can only afford one?

For most adults over 40, the highest-leverage single product is Vitamin D3 5000 IU + K2 MK-7 — the Endocrine Society deficiency rate runs 30–40% in US adults (25(OH)D <30 ng/mL), and D3 deficiency silently degrades immune, bone, cardiovascular, and mood endpoints simultaneously. For the under-40 energy/cognitive goal, the single highest-leverage pick is Pure NMN 500mg. For metabolic, it's Berberine HCL 500mg.

Dosing & timing

When is the best time to take my supplements?

Default: morning, with a meal containing ~10g of fat (most longevity actives are fat-soluble or have improved absorption with food). Most NAD+ precursors and sirtuin activators perform best earlier in the day to align with circadian NAD+ rhythm — Yoshino 2021 confirms morning dosing matches the natural diurnal NAD+ peak. The exceptions are listed in the table below.

Should I take supplements with or without food?

With food, almost always — fat improves absorption of fat-soluble actives (Vit D3+K2, Astaxanthin, Curcumin, Resveratrol, Omega-3, CoQ10), food buffers GI tolerability for berberine and NAC, and circadian-aligned morning meals match the diurnal NAD+ peak. The two intentional exceptions: NMN trials used both fed and fasted protocols with similar results — most users tolerate it either way; creatine is timing-agnostic but slightly better post-workout with carbs/protein.

How long until I notice anything?

Realistic expectations by week:

• Days 1–7: Magnesium glycinate evening dose can affect sleep onset; glycine pre-sleep can deepen slow-wave; otherwise nothing dramatic. If you feel "energy" on day 1, that's caffeine, not NAD+.
• Weeks 2–4: NMN/NAD+ users report 3pm energy stability; berberine users see fasting glucose dip 5–15 mg/dL (Yin 2008); collagen users see nail brittleness drop first.
• Weeks 4–8: Skin hydration measurably increases (Proksch 2014), workout recovery improves, sleep architecture stabilizes.
• Weeks 8–12: Subjective "younger metabolism" reports peak; A1C drops if elevated; hair-shaft caliber detectable.
• Months 3–12: Skin elasticity, mitochondrial endurance, and biological-age markers (epigenetic clocks, NAD+ assays) shift if measured.

If you're at full dose for 12 weeks and feel nothing, the differential is upstream: undiagnosed Vit D <30 ng/mL, ferritin <30 ng/mL, B12 <400 pg/mL, hypothyroid (TSH >4), undiagnosed sleep apnea, or sub-1.6 g/kg protein intake. See How It Works for the full week-by-week table.

Can I open the capsule and mix the contents?

Most capsules can be opened and mixed into food or yogurt — magnesium glycinate, NMN, NAC, taurine, glycine, creatine all do fine. Exceptions: enteric-coated Glutathione must stay coated (gastric acid degrades reduced GSH), Liposomal NAD+ liposomes are designed to survive intact, and Curcumin+BioPerine is bitter-pungent if opened. For powder formats use Multi Collagen Powder or NAD+ 1000mg Pure Focus drink mix.

Do I need a "rest day" or to cycle off?

Most foundational supplements (D3+K2, magnesium, omega-3, collagen, creatine, multivitamins) are designed for daily continuous use. Cycle these:

• Berberine — 8 weeks on, 2 weeks off (allows insulin sensitivity to recalibrate; Lan 2015 meta-analysis).
• Ashwagandha KSM-66 — 8–12 weeks on, 2–4 weeks off (HPA-axis tolerance avoidance).
• Senolytics (Fisetin/Quercetin) — pulsed 2 days/month, never daily (Yousefzadeh 2018).
• NAD+ precursors (NMN/NR/direct NAD+) — daily continuous is fine; some users do 5-on-2-off but no trial requires it.

What's the maximum number of supplements I should take?

There's no hard ceiling, but our advice: layer slowly. Start with foundation (3–5 SKUs) for 4 weeks, add a stack (2 SKUs) at week 4, add another at week 8, and reassess at week 12. Most full protocol users land at 8–12 daily SKUs total. Going from zero to 12 in week 1 is the most common reason people stop — the GI system needs ramp-up time. Read the "5 Common Starting Mistakes" section of Getting Started.

Safety, drug interactions & contraindications

I take a prescription medication. Are these safe?

Most longevity supplements are well-tolerated alongside most prescriptions, but several have meaningful interactions that require clinician review. The big ones:

• Warfarin / Coumadin — interacts with Vitamin K2 (offsets warfarin), Omega-3 (additive bleeding risk), Curcumin (CYP+antiplatelet), Garlic-class actives. If you're warfarin-managed, your INR will need re-titration after starting any of these — talk to your anticoagulation clinic first.
• Statins — deplete CoQ10 (Mortensen 2015 JACC), so CoQ10 400mg is the most common pairing — see CoQ10 and Statins. Berberine is itself a lipid-modifier — discuss combined dosing with your prescriber.
• Diabetes meds (metformin, sulfonylureas, insulin) — Berberine, ALA, and Cinnamon-class actives all lower glucose; combined dosing risks hypoglycemia. Berberine+metformin is studied but requires glucose monitoring — see Berberine vs Metformin.
• SSRIs / SNRIs / MAOIs — Ashwagandha, St. John's Wort-class actives (we don't sell), and some adaptogens have additive serotonergic risk. Ashwagandha specifically interacts with thyroid meds (suppresses TSH) and immunosuppressants (immune-modulating).
• Chemo / immunosuppressants (post-transplant) — most antioxidants (NAC, Vit C, Curcumin) theoretically blunt chemo cytotoxicity; senolytics target the same pathways some cancer therapies use. Pause supplements during active chemo and post-transplant immunosuppression unless your oncology team approves each one.
• Bisphosphonates (Fosamax, Boniva) — Magnesium, Calcium-class actives reduce absorption; separate dosing by 2 hours.

This list is not exhaustive — always tell your clinician your full supplement list. The Our Science page lists per-SKU mechanisms so your clinician can map them to your meds.

Are there any side effects?

Common, mild, and dose-related: berberine can cause GI upset in week 1 (split-dose, take with food, ramp from 250mg→500mg→750mg→1000mg over 2 weeks); NAC has a faint sulfur taste; NMN can cause mild flushing in 5% of users; resveratrol darkens urine slightly (harmless, anthocyanin metabolite). Less common: ashwagandha can suppress TSH in pre-existing hypothyroidism; high-dose biotin (10,000 mcg) can falsely elevate certain immunoassay-based lab tests (troponin, thyroid panel) — pause biotin 72 hr before lab draws. If anything is severe, stop and email support@truehealthprotocol.health.

Can I take these if I'm trying to conceive, pregnant, or nursing?

Trying to conceive: the Fertility collection is built for this — CoQ10 400mg, NAC, ALA, Omega-3 all have fertility evidence (Bentov 2010, Showell 2017 Cochrane).

Pregnant or nursing: the only products we recommend during pregnancy/nursing are: a high-quality prenatal (we don't sell one — your OB picks), Omega-3 DHA (200–500mg/day, fish oil quality matters), and Vitamin D3 (1,000–2,000 IU/day per ACOG). Pause all of the following during pregnancy/nursing: NMN, NAD+ precursors, Resveratrol, Berberine, Ashwagandha, Spermidine, Senolytics (Fisetin, Quercetin), Curcumin (high-dose), high-dose Biotin, and most adaptogens. Always confirm with your OB.

Are these vegan / vegetarian?

Most are. The non-vegan SKUs in our catalog are: Multi Collagen Complex, Multi Collagen Peptides Powder, Marine Collagen 5000mg, Beauty Stack (contains marine collagen), and Omega-3 Fish Oil (fish-derived). Vegan substitutions: Spermidine (wheat-germ), algae-based omega-3 (we don't currently stock — flagged for catalog expansion), and HA + Vit C for skin support without collagen. All other SKUs (NMN, NR, NAD+, resveratrol, berberine, ALA, NAC, glycine, taurine, magnesium, D3+K2, Vit C, biotin, ashwagandha, curcumin, fisetin, quercetin, apigenin, pterostilbene, spermidine, urolithin A, CoQ10, PQQ, TMG, glutathione, astaxanthin, creatine, HA) are vegan-friendly. Check the per-product label panel for confirmation.

Are these gluten-free / dairy-free / soy-free / non-GMO?

The full active catalog is gluten-free, dairy-free, soy-free, and non-GMO except where noted on the label. Capsules are vegetable cellulose (HPMC), not gelatin (with the exception of fish-collagen softgels). Manufacturing is in cGMP-certified, FDA-registered facilities; allergen statements are printed on every label.

I'm under 18 — can I take these?

No. Our supplements are formulated and dose-targeted for adults 18+. Pediatric supplementation should be supervised by a pediatrician — pediatric dosing, body-weight scaling, and developmental endocrine considerations are outside our protocol scope.

Quality, sourcing & third-party testing

Are your supplements third-party tested?

Yes. Every batch is tested by an independent ISO/IEC 17025-accredited lab for: identity (HPLC, GC-MS, FTIR), potency (active mg per capsule matches label), heavy metals (lead, arsenic, cadmium, mercury via ICP-MS, USP <232>/<233>), microbial load (USP <61>/<62>: total aerobic, yeast/mold, E. coli, Salmonella absent), and residual solvents where applicable. Certificates of Analysis (CoAs) are available on request — email support@truehealthprotocol.health with your batch number.

Where are your supplements manufactured?

In cGMP-certified, FDA-registered facilities in the United States. Each manufacturing partner has its own FDA registration number and facility audits on file. Raw materials are sourced from established ingredient houses with full traceability — see Ingredient Sourcing for the per-ingredient origin map (e.g., NMN source, β-NMN purity, MK-7 form, marine collagen species, fish oil IFOS/GOED rating).

Why does your label have full mg-doses while competitors hide behind "proprietary blends"?

Proprietary blends list the total blend weight without breaking down per-ingredient doses, which makes it impossible to verify whether the active dose matches the trial-validated dose. We publish every active milligram on every label because dose is the trial. Pterostilbene 100mg ≠ Pterostilbene 50mg. NMN 500mg ≠ NMN 125mg. Magnesium glycinate 400mg elemental ≠ glycinate-equivalent 100mg. Read Quality & Sourcing for the full standard.

What about heavy metals in fish oil and herbal supplements?

The two highest-risk categories are fish oil (mercury, PCBs) and turmeric (lead). Our Omega-3 2000mg is sourced from small wild-caught species (anchovy, sardine, mackerel) which are lower-trophic and accumulate less mercury, plus we test every batch via ICP-MS. Our Curcumin+BioPerine is sourced from a turmeric supplier with documented lead testing — turmeric lead-contamination is well-documented in the trade press, and we screen for it.

Why do some products say "best by" and others have a specific expiration?

"Best by" applies to dry encapsulated products with a 24-month stability window from manufacture; "expiration" applies to liquid, oil-based, or sensitive actives (Omega-3, Liposomal NAD+, Liposomal Vit C) where oxidation is a real concern. Store per label — most are room temperature (20–25°C, 68–77°F), out of direct sunlight; the Liposomal NAD+ and Omega-3 are best refrigerated after opening to extend shelf life.

Shipping, delivery & tracking

Where do you ship from? How long does delivery take?

We ship from a US fulfillment warehouse to all 50 states. Realistic delivery windows below — see Shipping Policy for full carrier & cutoff details.

How do I track my order?

You'll receive a confirmation email at checkout, and a second email with a tracking link once your order ships (usually within 1–2 business days). If you don't see either, check your spam folder, then email support@truehealthprotocol.health with your order number.

How much is shipping?

Shipping is calculated at checkout based on weight, destination, and method. Most US standard orders are flat-rate; orders over a threshold ship free (the threshold appears at cart). Expedited shipping is available at checkout. International orders include posted shipping rates; local import duties and VAT are the customer's responsibility per Shipping Policy.

Do you ship internationally?

Yes, to most countries. Restricted destinations are listed at checkout. Some active ingredients (e.g., NMN in certain jurisdictions, melatonin, kava) are regulated locally — we do not ship products into countries where they're prohibited. Customers are responsible for verifying local import legality and paying local duties/VAT.

My package was lost, damaged, or marked "delivered" but I don't have it. What now?

Email support@truehealthprotocol.health with your order number and a photo of any damage. We'll investigate with the carrier and either resend or refund — see Shipping Policy for the formal process. "Delivered but missing" claims should also be filed directly with the carrier (USPS, UPS) per their lost-package process.

Returns, refunds & the 30-day guarantee

What's your return policy?

30-day money-back guarantee from the delivery date. If you don't feel a difference or change your mind for any reason, email support@truehealthprotocol.health within 30 days of delivery with your order number. We'll process a refund to the original payment method (typically 3–7 business days to post). You don't have to return the product — keep it, give it away, or dispose of it. Full terms in Our 30-Day Guarantee and Refund Policy.

What if I'm past the 30-day window?

Email us anyway — we evaluate edge cases (carrier delay, medical event, defective product) outside the standard window. We'd rather make it right than win a returns dispute.

Can I return a partially used bottle?

Yes. The 30-day guarantee assumes you've actually tried the product, so partial-use returns are expected and refunded the same way as unopened ones.

How do I cancel an order before it ships?

Email support@truehealthprotocol.health with your order number ASAP. Most orders ship within 1–2 business days, so cancellation requests inside 12 hr typically catch the order before it leaves the warehouse. After shipment, treat it as a return under the 30-day guarantee.

Account, payment & subscriptions

What payment methods do you accept?

All major credit/debit cards (Visa, Mastercard, American Express, Discover), Apple Pay, Google Pay, Shop Pay, and PayPal where supported. All payment processing is PCI-compliant — we never see or store your card number. Currency: USD; international orders convert at your card-issuer's rate.

Do you offer subscriptions or auto-refill?

Subscription is rolling out; if it's not yet visible on the product page, you can email support@truehealthprotocol.health to request a manual refill schedule. Most users settle into a 30-day or 60-day cadence after their first month.

Do I need an account to order?

No — guest checkout is supported. Creating an account lets you track orders, store shipping addresses, and access order history.

Can I get a discount on my first order or a bulk discount?

First-order promo codes occasionally appear in the welcome email or homepage banner. Bulk/wholesale (5+ bottles of one SKU or practitioner accounts) — email support@truehealthprotocol.health with your use case for a custom quote.

Science & what to expect

How is this different from buying from Amazon or a vitamin shop?

Three differences: (1) dose & form match the trial — Pterostilbene 100mg not 50mg, magnesium glycinate not oxide, MK-7 not MK-4, multi-type collagen not bovine-only; (2) third-party CoAs on every batch with full heavy-metals, microbial, and identity testing — Amazon supply chains have a documented counterfeit problem (FDA Imports of Concern bulletins); (3) protocol context — we publish the trial reference, the mechanism, the timing, and the pairing for each product, so you're stacking deliberately rather than guessing. See Our Science for the full Hallmarks framework.

What is the López-Otín Hallmarks of Aging framework you keep referencing?

The 2013 Cell paper — and its 2023 update — by Carlos López-Otín and colleagues consolidated the molecular drivers of aging into 9 (now 12) hallmarks: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem-cell exhaustion, altered intercellular communication, plus the 2023 additions (disabled macroautophagy, chronic inflammation, dysbiosis). Our catalog is organized around which hallmarks each product targets — you can read the full mapping on Our Science.

What if 12 weeks at full dose feels like nothing?

Six likely upstream causes, in order of frequency: (1) Vitamin D <30 ng/mL (most common — fixable in 8 weeks with D3 5000 IU+K2); (2) ferritin <30 ng/mL (iron-deficient anemia, blood draw to confirm); (3) B12 <400 pg/mL (especially over-50 or vegan); (4) hypothyroid (TSH >4.0, T3 low); (5) undiagnosed sleep apnea; (6) chronic protein under-floor (<1.0 g/kg). Run an annual lab panel — see the How It Works Track-What-Matters section.

Are any of these "FDA approved" or "FDA tested"?

No, and they cannot be — FDA approves drugs, not dietary supplements. Supplements are regulated under DSHEA 1994; manufacturing is in FDA-registered cGMP-certified facilities, label claims comply with structure/function language under 21 CFR 101.93, but no individual supplement is "FDA approved." This is true for every legitimate US supplement company. Be skeptical of any vendor claiming "FDA approved" on a supplement.

Will I see results on a blood test?

Yes, on the right tests. Likely to move: 25(OH)D (D3 supplementation), fasting glucose & A1C (berberine, ALA), homocysteine (TMG, B-complex, methylation cofactors), hs-CRP (omega-3, curcumin), HDL/triglycerides (omega-3, niacin, berberine), ferritin (iron sources). Less commonly tested but available: NAD+ assay (specialty labs), epigenetic age clocks (Horvath, GrimAge — TruDiagnostic, Elysium), VO2 max (clinical exercise lab). Pair the supplement protocol with an annual lab panel for the strongest read on what's actually working.

About True Health Protocol

Who runs True Health Protocol?

An independent team building a longevity catalog around primary literature — not a multi-level marketing operation, not a re-bottler, not a franchise. We build, test, and ship our own SKUs. Read About True Health Protocol for the founding story and team.

Where can I read more?

Five reading paths in priority order:

• Getting Started — the on-ramp; pick your goal, your stack, your first dose.
• How It Works — the operating manual; week-by-week timeline, decision matrix, full-catalog map.
• Protocols — six pre-built stacks by goal (cellular longevity, beauty, metabolic, fertility, immunity, advanced NAD+).
• Our Science — the López-Otín Hallmarks framework underneath the catalog.
• The Protocol Library — 20 deep-dive articles on individual molecules, comparisons (NMN vs NR, marine vs bovine collagen), and stacking guides.

How do I contact you?

Email is fastest: support@truehealthprotocol.health — we respond within one business day. For business inquiries, registration, or address-of-record see Contact & Business Information.

Browse the catalog

Quick links into the 13 smart collections plus 5 curated bundles:

• Most Popular — the catalog's top movers, evidence-tier ranked.
• Foundational Health — the daily-seven baseline (D3+K2, magnesium, omega-3, collagen, Vit C, taurine, creatine).
• NAD+ Family — all 7 NAD+ precursor and direct-NAD+ SKUs in one place.
• NMN Supplements — entry-tier 500mg through double-strength 1000mg.
• Senolytics — Fisetin, Quercetin, Apigenin, pulsed senolytic protocols.
• Mitochondrial Renewal — Urolithin A, CoQ10, PQQ, ALA.
• Cardiovascular Longevity — omega-3, taurine, CoQ10, K2.
• Brain & Cognitive Longevity — creatine, omega-3, lion's-mane class actives.
• Metabolic — berberine, ALA, NMN, resveratrol AMPK+sirtuin stack.
• Collagen Supplements — multi-type, marine, beauty stack.
• Antioxidants — Vit C, NAC, glutathione, astaxanthin.
• Skin Protocol — full skin-aging stack (collagen+Vit C+biotin+HA+astaxanthin).
• Beauty & Anti-Aging — beauty-bundle entry tier.
• Fertility — CoQ10, NAC, ALA, omega-3 fertility stack.
• Longevity Essentials — the curated 13-product entry tier.
• Starter Bundles — the four pre-built starter packs.
• All Products — the full 40-SKU catalog.

Primary references

Trial-anchored citations referenced in this FAQ:

• López-Otín C, et al. The Hallmarks of Aging. Cell. 2013;153(6):1194–1217. (Updated 2023.)
• Yoshino M, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224–1229.
• Yamaguchi S, et al. NMN supplementation in healthy middle-aged adults: 12-week trial. Nutrients. 2022.
• Igarashi M, et al. Chronic NMN supplementation in healthy older men. npj Aging. 2022;8:5.
• Martens CR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+. Nat Commun. 2018;9:1286.
• Howitz KT, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003;425:191–196.
• Hubbard BP, et al. Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science. 2013;339:1216–1219.
• Yousefzadeh MJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18–28.
• Andreux PA, et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health. Nat Metab. 2019;1:595–603.
• Sekhar RV. GlyNAC supplementation improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, and muscle strength in older adults. Antioxidants. 2021;10(11):1815.
• Kumar P, et al. GlyNAC supplementation in older humans. Nutrients. 2022.
• Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712–717.
• Lan J, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipidemia and hypertension. J Ethnopharmacol. 2015;161:69–81.
• Ziegler D, et al. Efficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. Diabetes Care. 2011;34(9):2054–2060.
• Pullar JM, Carr AC, Vissers MCM. The roles of vitamin C in skin health. Nutrients. 2017;9(8):866.
• Shaw G, et al. Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis. Am J Clin Nutr. 2017;105(1):136–143.
• Proksch E, et al. Oral supplementation of specific collagen peptides has beneficial effects on human skin. Skin Pharmacol Physiol. 2014;27(1):47–55.
• Mortensen SA, et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: Q-SYMBIO. JACC Heart Fail. 2014;2(6):641–649.
• Abbasi B, et al. The effect of magnesium supplementation on primary insomnia in elderly. J Res Med Sci. 2012;17(12):1161–1169.
• Yamadera W, et al. Glycine ingestion improves subjective sleep quality. Sleep Biol Rhythms. 2007;5:126–131.
• Bauer J, et al. Evidence-based recommendations for optimal dietary protein intake in older people: PROT-AGE position paper. JAMDA. 2013;14(8):542–559.
• Bentov Y, et al. The contribution of mitochondrial function to reproductive aging. J Assist Reprod Genet. 2010;27:209–217.
• Showell MG, et al. Antioxidants for female subfertility. Cochrane Database Syst Rev. 2017;7:CD007807.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. The information on this page is for educational purposes only and is not a substitute for advice from a licensed healthcare professional. If you are pregnant, nursing, taking prescription medications, or have an existing medical condition, talk to your clinician before starting any supplement.